5,6-二氨基-1,3-二甲基尿苷水合物合成路线 （共 107 条）
反应条件
2: concentrated aqueous HCl
3: aqueous KOH / 100 - 110 °C
View Scheme
参考文献
Blicke; Schaaf
Journal of the American Chemical Society, 1956 , vol. 78, p. 5857,5860
反应条件
iron(III) chloride in water
0.0833333 h; Heating;
参考文献
Okamoto, Yoshihisa; Ogura, Kuniyoshi; Kurasawa, Yoshihisa; Kinoshita, Toshio
Heterocycles, 1984 , vol. 22, # 5 p. 1231 - 1234
反应条件
water
Erwaermen des Reaktionsprodukts mit wss.HCl;
参考文献
Pfleiderer
Chemische Berichte, 1955 , vol. 88, p. 1625,1630
反应条件
hydrogenchloride; water
1 h; Reflux;
参考文献
Mueller, Christa E.; Roegler, Carolin; Hockemeyer, Joerg
Heterocycles, 2009 , vol. 79, # C p. 703 - 720
参考文献
Blicke; Godt
Journal of the American Chemical Society, 1954 , vol. 76, p. 2798
参考文献
Bredereck et al.
Chemische Berichte, 1953 , vol. 86, p. 845,849
反应条件
1.1: hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane; water / 2 h / 20 °C / pH 5 - 6
2.1: sodium hydroxide / 1,4-dioxane; water / 2 h / Reflux
2.2: 0 °C / pH 4
View Scheme
参考文献
Okaecwe, Thokozile; Swanepoel, Abraham J.; Petzer, Anel; Bergh, Jacobus J.; Petzer, Jacobus P.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 14 p. 4336 - 4347
反应条件
N,N-dimethyl-aniline
参考文献
Hyperion, Inc.
Patent: US6060598 A1, 2000 ;
反应条件
1: dimethylformamide / 17 h / Ambient temperature
2: aq. NaOH / 1.5 h / 75 °C
View Scheme
参考文献
Boehringer Mannheim GmbH
Patent: US5595741 A1, 1997 ;
反应条件
1: With 2,3-dicyano-5,6-dichloro-p-benzoquinone in acetonitrile
T=20°C; 15 h;
2: With sodium hydroxide in water; acetonitrile
48 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/9091 A1, 2004 ;
Location in patent: Page/Page column 85-86 ;
WO 2004/009091 A1
