5,6-二氨基-1,3-二甲基尿苷水合物合成路线 （共 107 条）
反应条件
in toluene 1.) RT, 2.) reflux;
参考文献
Stanovnik, Branko; Bajt, OLiver; Balcic, Branko; Koren, Bozidar; Prhavc, Marija; et al.
Heterocycles, 1984 , vol. 22, # 7 p. 1545 - 1554
反应条件
1: Py 2: aq. NaOH View Scheme
参考文献
Shimada, Junichi; Suzuki, Fumio; Nonaka, Hiromi; Karasawa, Akira; Mizumoto, Hideaki; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 466 - 469
参考文献
Grundmann; Kreutzberger
Journal of the American Chemical Society, 1955 , vol. 77, p. 6559
参考文献
Bredereck et al.
Chemische Berichte, 1950 , vol. 83, p. 201,209
反应条件
hydrogenchloride; water 1 h; Reflux;
参考文献
Mueller, Christa E.; Roegler, Carolin; Hockemeyer, Joerg
Heterocycles, 2009 , vol. 79, # C p. 703 - 720
反应条件
2: concentrated aqueous HCl 3: Raney nickel; H2O View Scheme
参考文献
Blicke; Schaaf
Journal of the American Chemical Society, 1956 , vol. 78, p. 5857,5860
参考文献
Pesin,V.G. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1961 , vol. 31, p. 3000 - 3003,2798 - 2800
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in water; acetonitrile T=30 - 35°C; 2 h;
参考文献
Bandyopadhyay, Prabal; Agrawal, Sumit K.; Sathe, Manisha; Sharma, Pratibha; Kaushik
Tetrahedron, 2012 , vol. 68, # 20 p. 3822 - 3827
反应条件
1: 93 percent / ethanol 2: 85 percent / 85 percent m-CPBA / acetonitrile / Ambient temperature View Scheme
参考文献
Baziard-Mouysset, G.; Rached, A.; Younes, S.; Tournaire, C.; Stigliani, J. L.; et al.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 3 p. 253 - 260
反应条件
1: solid phase supported 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline / water; acetonitrile / 20 °C 2: sodium hydroxide / water; acetonitrile / Reflux View Scheme
参考文献
Bandyopadhyay, Prabal; Sathe, Manisha; Sharma, Pratibha; Kaushik
Tetrahedron Letters, 2012 , vol. 53, # 35 p. 4631 - 4635
