3-氧代-3-苯基丙酸叔丁酯合成路线 （共 33 条）
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.5 h;
2: With methanol in tetrahydrofuran
T=-78 - 0°C; Further stages.;
参考文献
Galliford, Chris V.; Scheidt, Karl A.
Chemical Communications, 2008 , # 16 p. 1926 - 1928
反应条件
1: acetic acid tert-butyl ester With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78°C; 0.5 h; Inert atmosphere;
2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran; hexane
T=-78°C; 1 h; Inert atmosphere;
参考文献
Peixoto, Philippe Alexandre; Boulange, Agathe; Leleu, Stephane; Franck, Xavier
European Journal of Organic Chemistry, 2013 , # 16 p. 3316 - 3327
反应条件
palladium(II) 2,4-pentanedionate; tributyl-amine; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene
T=90°C; P=7500.75 Torr; 15 h; Inert atmosphereAutoclaveSchlenk technique;
参考文献
Wahl, Benoit; Bonin, Helene; Mortreux, Andre; Sauthier, Mathieu; Giboulot, Steven; Liron, Frederic; Poli, Giovanni
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 16 p. 3105 - 3114,10
反应条件
Dess-Martin periodane in dichloromethane
0.0833333 h;
参考文献
Meyer, Stephanie D.; Schreiber, Stuart L.
Journal of Organic Chemistry, 1994 , vol. 59, # 24 p. 7549 - 7552
反应条件
ammonia in tetrahydrofuran
参考文献
Lonza Ltd.
Patent: US5144057 A1, 1992 ;
反应条件
1: acetic acid tert-butyl ester With Zn(2,2,6,6-tetramethylpiperidide)2 in toluene
T=20°C; 1 h; Microwave irradiation;
2: morpholino benzoate in tetrahydrofuran; toluene
T=60°C; Microwave irradiation; Time;
参考文献
McDonald, Stacey L.; Wang, Qiu
Chemical Communications, 2014 , vol. 50, # 19 p. 2535 - 2538
反应条件
1: acetic acid tert-butyl ester With Zn(2,2,6,6-tetramethylpiperidide)2 in toluene
T=20°C; 1 h; Microwave irradiation;
2: BzO-NEt2 in tetrahydrofuran; toluene
T=60°C; Microwave irradiation; Time;
参考文献
McDonald, Stacey L.; Wang, Qiu
Chemical Communications, 2014 , vol. 50, # 19 p. 2535 - 2538
反应条件
sodium hydroxide in hexane; water
T=35°C; 0.5 h;
参考文献
Kluger, Ronald; Brandl, Michael
Journal of Organic Chemistry, 1986 , vol. 51, # 21 p. 3964 - 3968
反应条件
dicyclohexyl-carbodiimide in acetonitrile
T=20°C; 6 h;
参考文献
Yoshida, Masanori; Kubara, Ami; Hara, Shoji
Chemistry Letters, 2013 , vol. 42, # 2 p. 180 - 182
反应条件
sodium amide in diethyl ether
3 h; Heating;
参考文献
Cocco; Maccioni; Plumitallo
Farmaco, Edizione Scientifica, 1985 , vol. 40, # 4 p. 272 - 284
