3-氧代-3-苯基丙酸叔丁酯合成路线 （共 33 条）
反应条件
1: 84 percent / BF3*Et2O / tetrahydrofuran / 12 h / 60 °C
2: 75 percent / tetrahydrofuran; 2-methyl-propan-2-ol / Heating
3: 2 N H2SO4 / tetrahydrofuran
View Scheme
参考文献
Fustero, Santos; Diaz, Ma. Dolores; Carlon, Raquel Perez
Tetrahedron Letters, 1992 , vol. 34, # 4 p. 725 - 728
反应条件
ammonium hydroxide; ammonium chloride in water
T=42°C; 0.333333 h; Yield given;
参考文献
Sato, Masayuki; Ogasawara, Hiromichi; Oi, Keiichi; Kato, Tetsuzo
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 6 p. 1896 - 1901
反应条件
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1.5 h / 20 °C / |Inert atmosphere
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere
3.2: 1 h / -78 °C / |Inert atmosphere
View Scheme
参考文献
Peixoto, Philippe Alexandre; Boulange, Agathe; Leleu, Stephane; Franck, Xavier
European Journal of Organic Chemistry, 2013 , # 16 p. 3316 - 3327
反应条件
1.1: triethylamine / dichloromethane / 2 h / 20 °C
2.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 0.5 h / -78 °C / |Inert atmosphere
2.2: 1 h / -78 °C / |Inert atmosphere
View Scheme
参考文献
Peixoto, Philippe Alexandre; Boulange, Agathe; Leleu, Stephane; Franck, Xavier
European Journal of Organic Chemistry, 2013 , # 16 p. 3316 - 3327
反应条件
1: acetic acid tert-butyl ester With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 0.25 h;
2: N-Methoxy-N-methyl-benzamide in tetrahydrofuran
T=-78°C; 2 h; Overall yield = 88 percent;
参考文献
Sather, Aaron C.; Berryman, Orion B.; Moore, Curtis E.; Rebek, Julius
Chemical Communications, 2013 , vol. 49, # 57 p. 6379 - 6381
反应条件
1: acetic acid tert-butyl ester With Zn(2,2,6,6-tetramethylpiperidide)2 in toluene
T=20°C; 1 h; Microwave irradiation;
2: morpholino benzoate With [2,2']bipyridinyl; copper (I) cyanide in tetrahydrofuran; toluene
T=20°C; 24 h; Microwave irradiation; Reagent/catalyst;
参考文献
McDonald, Stacey L.; Wang, Qiu
Chemical Communications, 2014 , vol. 50, # 19 p. 2535 - 2538
反应条件
chromium(VI) oxide in pyridine; dichloromethane
参考文献
Mioskowski, Charles; Solladie, Guy
Tetrahedron, 1980 , vol. 36, # 2 p. 227 - 236
反应条件
sulfuric acid in tetrahydrofuran
参考文献
Fustero, Santos; Diaz, Ma. Dolores; Carlon, Raquel Perez
Tetrahedron Letters, 1992 , vol. 34, # 4 p. 725 - 728
反应条件
1: 75 percent / tetrahydrofuran; 2-methyl-propan-2-ol / Heating
2: 2 N H2SO4 / tetrahydrofuran
View Scheme
参考文献
Fustero, Santos; Diaz, Ma. Dolores; Carlon, Raquel Perez
Tetrahedron Letters, 1992 , vol. 34, # 4 p. 725 - 728
反应条件
1: t-BuOCO2Me With sodium hydride in toluene
RefluxInert atmosphere;
2: acetophenone in toluene
RefluxInert atmosphere;
参考文献
Guizzetti, Stefania; Benaglia, Maurizio; Bonsignore, Martina; Raimondi, Laura
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 3 p. 739 - 743
