1,4-二硫杂螺[4.5]癸烷-8-酮合成路线 （共 10 条）
反应条件
lithium aluminium tetrahydride in diethyl ether T=0°C; 1 h;
参考文献
Takemura, Tetsuo; Hosoya, Yoshiko; Mori, Nobuo
Canadian Journal of Chemistry, 1990 , vol. 68, # 4 p. 523 - 529
反应条件
phosphoric acid; dicyclohexyl-carbodiimide in dimethyl sulfoxide; benzene
3 h;
参考文献
Meyer, Walter L.; Brannon, Michael J.; Burgos, Celmira da G.; Goodwin, Thomas E.; Howard, Ralph W.
Journal of Organic Chemistry, 1985 , vol. 50, # 4 p. 438 - 447
反应条件
1: 100 percent / aq. KOH / methanol / 3 h / Heating
2: 100 percent / 99percent dicyclohexylcarbodiimide, H3PO4 / dimethylsulfoxide; benzene / 3 h
View Scheme
参考文献
Meyer, Walter L.; Brannon, Michael J.; Burgos, Celmira da G.; Goodwin, Thomas E.; Howard, Ralph W.
Journal of Organic Chemistry, 1985 , vol. 50, # 4 p. 438 - 447
反应条件
1: 87 percent / Et2O*BF3 / 0.17 h / 0 °C
2: 100 percent / aq. KOH / methanol / 3 h / Heating
3: 100 percent / 99percent dicyclohexylcarbodiimide, H3PO4 / dimethylsulfoxide; benzene / 3 h
View Scheme
参考文献
Meyer, Walter L.; Brannon, Michael J.; Burgos, Celmira da G.; Goodwin, Thomas E.; Howard, Ralph W.
Journal of Organic Chemistry, 1985 , vol. 50, # 4 p. 438 - 447
反应条件
toluene-4-sulfonic acid in benzene
Heating;
参考文献
Takemura, Tetsuo; Hosoya, Yoshiko; Mori, Nobuo
Canadian Journal of Chemistry, 1990 , vol. 68, # 4 p. 523 - 529
反应条件
1: HCl / CHCl3 / 4 h / Ambient temperature
2: 43 percent / pyridinium dichromate / dimethylformamide / 6 h / 0 °C
View Scheme
参考文献
Bell, Vivien L.; Holmes, Andrew B.
Synthetic Communications, 1982 , vol. 12, # 4 p. 323 - 326
反应条件
1: Birch reduction
2: HCl / CHCl3 / 4 h / Ambient temperature
3: 43 percent / pyridinium dichromate / dimethylformamide / 6 h / 0 °C
View Scheme
参考文献
Bell, Vivien L.; Holmes, Andrew B.
Synthetic Communications, 1982 , vol. 12, # 4 p. 323 - 326
反应条件
1: 82 percent / chromium trioxide / acetic acid; H2O
2: 92 percent / toluene-p-sulphonic acid / benzene / Heating
3: 83 percent / sodium methoxide / methanol / 15 h / Heating
4: 34 percent / chromium trioxide / pyridine / 72 h
View Scheme
参考文献
Crombie, Leslie; Crombie, W. Mary L.; Jamieson, Sally V.; Tuchinda Patoomratana; Whitaker, Alison J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1485 - 1492
反应条件
1: 40 percent / NBS / CH2Cl2
2: 98 percent / Li; ammonia (liq.)
View Scheme
参考文献
Tan, Qiang; Birzin, Elizabeth T.; Chan, Wanda; Yang, Yi Tien; Pai, Lee-Yuh; Hayes, Edward C.; Dasilva, Carolyn A.; Dininno, Frank; Rohrer, Susan P.; Schaeffer, James M.; Hammond, Milton L.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3753 - 3755
反应条件
in tetrahydrofuran
1 h; Heating;
参考文献
Crombie, Leslie; Crombie, W. Mary L.; Jamieson, Sally V.; Tuchinda Patoomratana; Whitaker, Alison J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1485 - 1492
