N,N-二乙基-1-萘羧酰胺合成路线 （共 22 条）
反应条件
1: pyridine / 48 h / 0 °C
2: 63 percent / tetrabutylammonium fluoride / acetonitrile / Ambient temperature
3: 1.) H2, 2.) HCl / 1.) Pd-C / 1.) ethanol, 2.) ethanol, reflux
View Scheme
参考文献
Shankaran, K.; Snieckus, V.
Tetrahedron Letters, 1984 , vol. 25, # 27 p. 2827 - 2830
反应条件
1: naphthalene-1-carboxylic acid With thionyl chloride in benzene
Heating;
2: diethylamine in benzene
T=20°C;
参考文献
Pradhan, Tarun Kanti; De, Asish; Mortier, Jacques
Tetrahedron, 2005 , vol. 61, # 38 p. 9007 - 9017
反应条件
1: SOCl2, dimethyl formamide / benzene / 2 h
2: 18.5 g / diethyl ether / 1 h / 0 °C
View Scheme
参考文献
Harvey, Ronald G.; Cortez, Cecilia; Jacobs, Stephen A.
Journal of Organic Chemistry, 1982 , vol. 47, # 11 p. 2120 - 2125
反应条件
hydrogenchloride; hydrogen; palladium on activated charcoal
1.) ethanol, 2.) ethanol, reflux; Multistep reaction;
参考文献
Shankaran, K.; Snieckus, V.
Tetrahedron Letters, 1984 , vol. 25, # 27 p. 2827 - 2830
反应条件
tin(IV) chloride
T=130 - 140°C; 10 h; var. solvents, other reagent - AlCl3, var. temperatures; Product distribution;
参考文献
Isakova, A. P.; Naumov, Yu. A.; Nikeryasova, S. V.; Fomichev, A. A.; Murugova, L. A.
Journal of Organic Chemistry USSR (English Translation), 1980 , vol. 16, # 3 p. 558 - 561
Zhurnal Organicheskoi Khimii, 1980 , vol. 16, # 3 p. 639 - 642
反应条件
sec.-butyllithium in tetrahydrofuran
T=-78 - 23°C; 20 h;
参考文献
MERCK PATENT GMBH; MITCHELL, William; WANG, Changsheng; D'LAVARI, Mansoor; BLOUIN, Nicolas; TIERNEY, Steven
Patent: WO2012/76092 A1, 2012 ;
Location in patent: Page/Page column 55 ;
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether
1.) -78 deg C, 1 h, 2.) -78 deg C -> RT, 12 h;
参考文献
Watanabe; Snieckus
Journal of the American Chemical Society, 1980 , vol. 102, # 4 p. 1457 - 1460
反应条件
1: 1.) TMEDA, triphenylmethyl chloride, sec-BuLi / 1.) ether, cyclohexane, -78 deg C, 1 h, 2.) a) -78 deg, 1 h, b) room temp., 3 h
2: 80 percent / HI, H3PO2 / acetic acid / 240 h / Heating
View Scheme
参考文献
Harvey, Ronald G.; Cortez, Cecilia; Jacobs, Stephen A.
Journal of Organic Chemistry, 1982 , vol. 47, # 11 p. 2120 - 2125
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether
1.) -78 deg C, 1 h, 2.) -78 deg C -> RT, 12 h;
参考文献
Watanabe; Snieckus
Journal of the American Chemical Society, 1980 , vol. 102, # 4 p. 1457 - 1460
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium; trityl chloride
1.) ether, cyclohexane, -78 deg C, 1 h, 2.) a) -78 deg C, 1 h, b) room temp., 3 h; Yield given. Multistep reaction;
参考文献
Harvey, Ronald G.; Cortez, Cecilia; Jacobs, Stephen A.
Journal of Organic Chemistry, 1982 , vol. 47, # 11 p. 2120 - 2125
