反应条件
1.1: pivalic acid sodium salt / 1-methyl-pyrrolidin-2-one / 2.75 h / 20 - 50 °C / Large scale reaction
2.1: sulfuric acid; water / 50 - 100 °C / Large scale reaction
3.1: sodium ethanolate / tetrahydrofuran / 10 - 20 °C / Large scale reaction
3.2: 2 h / 20 °C
4.1: palladium 10 on activated carbon; ammonium formate; acetic acid / ethanol; water / 3.25 h / 35 °C / Large scale reaction
5.1: ammonia / ethylene glycol / 6.92 h / 25 - 65 °C
View Scheme
参考文献
Huang, Bao-Guo; Kubiak, Gregory; Shay, John J.; Pemberton, Clive; Peers, James; Hanna, Reda G.; Powers, Matthew R.; Gamboa, Juan A.; Gelormini, Ann M.; Yarabe, Hyacinthe; Rudisill, Duane E.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1040 - 1045