6-乙酰基-2(3H)-苯唑酮合成路线 （共 9 条）
反应条件
polyphosphoric acid T=90 - 100°C; 3 h;
参考文献
Bali, Alka; Ohri, Ruchika; Deb, Pran Kishore
European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 397 - 405
反应条件
aluminium trichloride in N,N-dimethyl-formamide Acetylation; Friedel-Crafts reaction; 3.5 h; Heating; Product distribution; Further Variations:SolventsCatalysts;
参考文献
Liacha, Messaoud; Yous, Said; Poupaert, Jacques H.; Depreux, Patrick; Aichaoui, Hocine
Monatshefte fur Chemie, 1999 , vol. 130, # 11 p. 1393 - 1397
反应条件
aluminium trichloride in N,N-dimethyl-formamide T=75°C; 2 h; regioselectivity in the C-acylation; other substrates;
参考文献
Aichaoui, Hocine; Poupaert, Jacques H.; Lesieur, Daniel; Henichart, Jean-Pierre
Tetrahedron, 1991 , vol. 47, # 33 p. 6649 - 6654
Title/Abstract Full Text View citing articles Show Details
Aichaoui, Hocine; Lesieur, Daniel; Henichart, Jean-Pierre
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 1 p. 171 - 175
反应条件
aluminium trichloride; N,N-dimethyl-formamide T=80°C; 3.5 h;
参考文献
Aichaoui, Hocine; Poupaert, Jacques H.; Lesieur, Daniel; Henichart, Jean-Pierre
Bulletin des Societes Chimiques Belges, 1992 , vol. 101, # 12 p. 1053 - 1060
反应条件
PPA T=110°C; 1.5 h; acyl migration in 3-acyl-2,3-dihydrobenzoxazol-2-one in the presence of polyphosphoric acid; Product distribution;
参考文献
Cotelle, Nicole; Cotelle, Philippe; Lesieur, Daniel
Synthetic Communications, 1989 , vol. 19, # 18 p. 3259 - 3266
反应条件
in acetonitrile 48 h; Irradiation;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 52, p. 1135 - 1138
反应条件
sodium hydroxide
4 h; Heatingother 6-acyl-2(3H)-benzoxazolinones;
参考文献
Aichaoui, Hocine; Lesieur, Isabelle; Henichart, Jean-Pierre
Synthesis, 1990 , # 8 p. 679 - 680
反应条件
1: 6-acetylbenzoxazolin-2(3H)-one With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.333333 h;
2: methyl iodide in N,N-dimethyl-formamide
T=0 - 20°C; 1.5 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1785426 A1, 2007 ;
Location in patent: Page/Page column 40 ;
反应条件
potassium hydroxide in ethanol
3 h;
参考文献
Delot, Marc; Carato, Pascal; Furman, Christophe; Lemoine, Amelie; Lebegue, Nicolas; Berthelot, Pascal; Yous, Said
Synthesis, 2009 , # 22 art. no. Z13909SS, p. 3819 - 3822
