4,5,6,7-四氢噻吩并[3.2-c]吡啶合成路线 （共 46 条）
反应条件
1.1: titanium(IV) isopropylate / 2 h / 80 °C / Inert atmosphere 2.1: acetic anhydride 2.2: 0 - 70 °C / Inert atmosphere 2.3: 1.5 h / 70 °C / Inert atmosphere 3.1: hydrogenchloride; water / ethanol / 4 h / Inert atmosphere; Reflux View Scheme
参考文献
Heterocycles, , vol. 81, # 8 p. 1903 - 1921
反应条件
1: triethylsilane; trifluoroacetic acid / acetonitrile / 12 h / 0 - 20 °C 2: water; sodium periodate; osmium(VIII) oxide / tetrahydrofuran; tert-butyl alcohol / 1 h / 0 °C 3: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 2.5 h / -78 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 40 p. 5464 - 5466
反应条件
hydrogenchloride; formic acid; dimethylsulfide; hydrogen sulfide; titanium tetrachloride; ozone; trifluoroacetic acid Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 34, # 12 p. 2263 - 2267
反应条件
1: Et3N; pyridine 2: 50 percent aq. KOH 3: 83 percent / 3.5 N aq. KOH / Heating 4: 95 percent / 47 percent aq. HBr / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2549 - 2552
反应条件
1: 83 percent / 3.5 N aq. KOH / Heating 2: 95 percent / 47 percent aq. HBr / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 18 p. 2549 - 2552
反应条件
1: 1.) O3, CF3COOH, 2.) Me2S / 1.) CH2Cl2, CH3OH, -60 deg C, 2.) CH2Cl2, CH3OH, 0 deg C 2: H2S(g), HCl(g), TiCl4 / 24 h / 0 - 20 °C View Scheme
参考文献
Heterocycles, , vol. 34, # 12 p. 2263 - 2267
反应条件
hydrogenchloride; formic acid; dimethylsulfide; hydrogen sulfide; titanium tetrachloride; ozone; trifluoroacetic acid Yield given. Multistep reaction;
参考文献
Heterocycles, , vol. 34, # 12 p. 2263 - 2267
反应条件
potassium carbonate in ethanol 4 h; Heating;
参考文献
Syntex (U.S.A.) Inc.
Patent: US4997945 A1, 1991 ;
反应条件
1: 1-bromo-2-chloro-benzene With ethylene dibromide; trifluoroacetic acid; cobalt(II) dibromide; zinc in acetonitrile T=20°C; 0.5 h; Inert atmosphere; 2: formaldehyd; 4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine in acetonitrile T=60°C; 1 h; Inert atmosphere;
参考文献
Isabelle, Aillaud; Haurena, Caroline; Gall, Erwan Le; Martens, Thierry; Ricci, Gino
Molecules, 2010 , vol. 15, # 11 p. 8144 - 8155
反应条件
hydrogenchloride; sodium hydrogencarbonate in ethanol
参考文献
Sanofi
Patent: US5132435 A1, 1992 ;
