6-乙酰基-3-甲基苯并噁唑-2(3h)-酮合成路线 （共 11 条）
反应条件
1: 60 percent / NaOH 2: 75 percent / C2H5ONa / dimethylsulfoxide / 3 h / Ambient temperature View Scheme
参考文献
Moussavi, Ziaeddine; Lesieur, Daniel; Lespagnol, Charles; Sauzieres, Jacques; Olivier, Philippe
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 55 - 60
反应条件
1: 60 percent / NaOH 2: 75 percent / C2H5ONa / dimethylsulfoxide / 3 h / Ambient temperature 3: 65 percent / HCl gas / ethanol / 2 h / Ambient temperature View Scheme
参考文献
Moussavi, Ziaeddine; Lesieur, Daniel; Lespagnol, Charles; Sauzieres, Jacques; Olivier, Philippe
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 55 - 60
反应条件
1: 60 percent / NaOH 2: 80 percent / C2H5ONa / dimethylsulfoxide / 3 h / Ambient temperature 3: 70 percent / HCl gas / ethanol / 2 h / Ambient temperature View Scheme
参考文献
Moussavi, Ziaeddine; Lesieur, Daniel; Lespagnol, Charles; Sauzieres, Jacques; Olivier, Philippe
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 55 - 60
反应条件
1: 60 percent / NaOH 2: 75 percent / C2H5ONa / dimethylsulfoxide / 3 h / Ambient temperature 3: 65 percent / HCl gas / ethanol / 2 h / Ambient temperature View Scheme
参考文献
Moussavi, Ziaeddine; Lesieur, Daniel; Lespagnol, Charles; Sauzieres, Jacques; Olivier, Philippe
European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 55 - 60
反应条件
1: 60 percent / NaOH 2: 75 percent / C2H5ONa / dimethylsulfoxide / 3 h / Ambient temperature View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 24, p. 55 - 60
反应条件
1: 6-acetylbenzoxazolin-2(3H)-one With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.333333 h;
2: methyl iodide in N,N-dimethyl-formamide
T=0 - 20°C; 1.5 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1785426 A1, 2007 ;
Location in patent: Page/Page column 40 ;
反应条件
polyphosphoric acid
T=90°C; Friedel Crafts acylation; 0.366667 h; Microwave irradiation;
参考文献
Baytas, Sultan; Turan Dural, Niludie Nermin; Oezkan, Yesim; Simsek, Hasan Bolkan; Guersel, Tuerkiz; Uenlue, Serdar
Turkish Journal of Chemistry, 2012 , vol. 36, # 3 p. 367 - 382
反应条件
aluminium trichloride in N,N-dimethyl-formamide
T=75°C; 2 h;
参考文献
Aichaoui, Hocine; Lesieur, Daniel; Henichart, Jean-Pierre
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 1 p. 171 - 175
反应条件
aluminium trichloride in N,N-dimethyl-formamide
Acetylation; Friedel-Crafts reaction; 2.5 h; Heating;
参考文献
Liacha, Messaoud; Yous, Said; Poupaert, Jacques H.; Depreux, Patrick; Aichaoui, Hocine
Monatshefte fur Chemie, 1999 , vol. 130, # 11 p. 1393 - 1397
反应条件
1: 0.25 h / 140 °C / Microwave irradiation
2: sodium hydroxide / 0.5 h
3: PPA / 0.37 h / 90 °C / Microwave irradiation
View Scheme
参考文献
Baytas, Sultan; Turan Dural, Niludie Nermin; Oezkan, Yesim; Simsek, Hasan Bolkan; Guersel, Tuerkiz; Uenlue, Serdar
Turkish Journal of Chemistry, 2012 , vol. 36, # 3 p. 367 - 382
