乙基4-环己基-4-氧代丁酸酯合成路线 （共 10 条）
反应条件
water; trifluoroacetic acid in dichloromethane T=20°C; 2.5 h;
参考文献
Sato, Tsuneo; Okazaki, Hiroshi; Otera, Junzo; Nozaki, Hitosi
Journal of the American Chemical Society, 1988 , vol. 110, # 15 p. 5209 - 5211
反应条件
3-methyl-2-amino-pyridine; benzoic acid; Wilkinson's catalyst in toluene T=130°C; 6 h;
参考文献
Jo, Eun-Ae; Jun, Chul-Ho
European Journal of Organic Chemistry, 2006 , # 11 p. 2504 - 2507
反应条件
tin(IV) chloride in dichloromethane T=-78°C;
参考文献
Journal of the American Chemical Society, , vol. 106, p. 1759
反应条件
1: 2) t-BuOK / 1) THF, 0 deg C, 0.5 h; THF, -78 deg C, 0.5 h 2: 79 percent / CF3COOH, H2O / CH2Cl2 / 2.5 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 15 p. 5209 - 5211
反应条件
water; tin(IV) chloride 1.) methylene chloride, 15 min, -78 deg C, 15 min, -30 deg C; Yield given. Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 106, p. 1759
参考文献
Journal of Organic Chemistry, , vol. 42, p. 4166 - 4167
反应条件
sodium hydride; toluene-4-sulfonic acid 1.) THF, RT, 2 h, 2.) toluene, reflux, 2 h; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 27 p. 5420 - 5428
反应条件
(i) (thioacetalization), (ii) Raney-Ni; Multistep reaction;
参考文献
Nakamura,E. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 4166 - 4167
反应条件
sodium hydroxide 12 h; Ambient temperature;
参考文献
Shinkai, Hisashi; Ozeki, Hidekazu; Motomura, Takahisa; Ohta, Takeshi; Furukawa, Noboru; Uchida, Itsuo
Journal of Medicinal Chemistry, 1998 , vol. 41, # 27 p. 5420 - 5428
反应条件
(i) (thioacetalization), (ii) (alkaline hydrolysis), (iii) /BRN= 3587162/, CuCl2, CuO; Multistep reaction;
参考文献
Nakamura,E. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 4166 - 4167
