乙基N-[二(甲硫基)亚甲基]甘氨酸酯合成路线 （共 14 条）
反应条件
1: 1.) NaOtBu / 1.) DMF; 2.) DMF, 2 h, room temp. 2: dimethylformamide / 2 h / Ambient temperature View Scheme
参考文献
Doelling, Wolfgang; Kindt, Petra; Augustin, Manfred
Zeitschrift fuer Chemie (Stuttgart, Germany), 1987 , vol. 27, # 6 p. 212 - 213
参考文献
Alvarez-Ibarra, C.; Davila, E.; Mateo, A.; Ortiz, P.; Quiroga, M. L.
Tetrahedron Letters, 1987 , vol. 28, # 52 p. 6667 - 6670
反应条件
1: carbon disulfide; glycine ethyl ester hydrochloric acid With triethylamine in chloroform
1 h;
2: methyl iodide With potassium carbonate in chloroform
Heating;
参考文献
Bhuiyan; Rahman, Khandker M. M.; Hossain; Rahim
Croatica Chemica Acta, 2005 , vol. 78, # 4 p. 633 - 636
反应条件
1: carbon disulfide; glicine ethyl ester hydrochloride With triethylamine in dichloromethane
T=20°C; 0.5 h;
2: methyl iodide With triethylamine in dichloromethane
Heating;
参考文献
Krishnaswamy; Govande; Gumaste; Bhawal; Deshmukh
Tetrahedron, 2002 , vol. 58, # 11 p. 2215 - 2225
反应条件
potassium carbonate in water; dimethyl sulfoxide
0 deg C, 15 min., 20 deg C, 2 h;
参考文献
Ibarra, Alvarez C.; Cereceda, J. A.; Ortiz, P.; Vicente, A.; Quiroga, M. L.
Tetrahedron Letters, 1985 , vol. 26, # 2 p. 243 - 246
反应条件
potassium tert-butylate
1) THF, -78 deg C, 0,5 h, 2) THF, 0 deg C, 0,5 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Alvarez-Ibarra, Carlos; Lopez-Ranz, Maria M.; Lopez-Sanchez, Maria I.; Orellana, Guillermo; Ortiz, Paloma; Quiroga, Maria L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1577 - 1584
反应条件
potassium tert-butylate in tetrahydrofuran
T=-78 - 20°C;
参考文献
Casar, Zdenko; Majcen-Le Marechal, Alenka; Lorcy, Dominique
New Journal of Chemistry, 2003 , vol. 27, # 11 p. 1622 - 1626
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-78 - 20°C;
参考文献
Casar, Zdenko; Majcen-Le Marechal, Alenka; Lorcy, Dominique
New Journal of Chemistry, 2003 , vol. 27, # 11 p. 1622 - 1626
反应条件
potassium tert-butylate in tetrahydrofuran
T=-78 - 20°C;
参考文献
Casar, Zdenko; Majcen-Le Marechal, Alenka; Lorcy, Dominique
New Journal of Chemistry, 2003 , vol. 27, # 11 p. 1622 - 1626
反应条件
lithium diisopropyl amide in tetrahydrofuran
T=-78 - 20°C;
参考文献
Casar, Zdenko; Majcen-Le Marechal, Alenka; Lorcy, Dominique
New Journal of Chemistry, 2003 , vol. 27, # 11 p. 1622 - 1626
