4,4'-(2,5-呋喃二基)二-苯甲腈合成路线 （共 9 条）
反应条件
1: 75 percent / 30percent aq. NaOH / methanol / 40 h / Heating 2: 84 percent / SOCl2 / benzene / 2.5 h / Heating 3: 80 percent / CH2Cl2 / 7 h / Ambient temperature View Scheme
参考文献
Boykin, David W.; Kumar, Arvind; Xiao, Ge; Wilson, W. David; Bender, Brendan C.; McCurdy, Donald R.; Hall, James Edwin; Tidwell, Richard R.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 1 p. 124 - 129
反应条件
lithium diisopropyl amide in tetrahydrofuran; n-heptane; chloroform
参考文献
University of Massachusetts Medical Center
Patent: US5935776 A1, 1999 ;
反应条件
potassium acetate; palladium diacetate in N,N-dimethyl acetamide
T=130°C; 16 h; Autoclave; regioselective reaction;
参考文献
Fu, Hai Yan; Doucet, Henri
European Journal of Organic Chemistry, 2011 , # 35 p. 7163 - 7173
反应条件
potassium acetate; palladium diacetate in N,N-dimethyl acetamide
T=130°C; 16 h; regioselective reaction;
参考文献
Fu, Hai Yan; Doucet, Henri
European Journal of Organic Chemistry, 2011 , # 35 p. 7163 - 7173
反应条件
potassium acetate; palladium diacetate in N,N-dimethyl acetamide
T=150°C; 20 h; Inert atmosphere; regioselective reaction;
参考文献
Fu, Hai Yan; Doucet, Henri
European Journal of Organic Chemistry, 2011 , # 35 p. 7163 - 7173
反应条件
potassium acetate; palladium diacetate in N,N-dimethyl acetamide
T=130°C; 16 h;
参考文献
Fu, Hai Yan; Doucet, Henri
European Journal of Organic Chemistry, 2011 , # 35 p. 7163 - 7173
反应条件
tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane
T=85°C; Stille reaction;
参考文献
de Oliveira, Renata B.; de Souza-Fagundes, Elaine M.; Siqueira, Helen A.J.; Leite, Rodrigo S.; Donnici, Claudio L.; Zani, Carlos L.
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 6 p. 756 - 760
反应条件
(i) HCl, EtOH, dioxane, (ii) /BRN= 605263/; Multistep reaction;
参考文献
Das; Boykin
Journal of Medicinal Chemistry, 1977 , vol. 20, # 4 p. 531 - 536
反应条件
(i) HCl, EtOH, dioxane, (ii) /BRN= 605277/; Multistep reaction;
参考文献
Das; Boykin
Journal of Medicinal Chemistry, 1977 , vol. 20, # 4 p. 531 - 536
