1.1: chlorosulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice 1.2: pH ~ 6 - ~ 11 2.1: sodium tetrahydroborate; methanol / 1 h / 20 °C 3.1: hydrogen; acetic acid / palladium 10 on activated carbon / methanol / 72 h 3.2: pH ~ 10 View Scheme

1.1: chlorosulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice 1.2: pH ~ 6 - ~ 11 2.1: sodium tetrahydroborate; methanol / 1 h / 20 °C View Scheme

1.1: chlorosulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice 1.2: pH ~ 6 - ~ 11 2.1: sodium tetrahydroborate; methanol / 1 h / 20 °C 3.1: hydrogen; acetic acid / palladium 10 on activated carbon / methanol / 72 h 3.2: pH ~ 10 4.1: 18 h / 75 °C / Neat (no solvent) View Scheme

1: With water; sodium hydroxide T=120°C; 1 h; 2: With hydrogenchloride in water pH=4 - 5; Cooling with ice;

1.1: 50 h / 150 °C 2.1: sodium hydroxide; water / 1 h / 20 - 120 °C 2.2: pH ~ 4 - ~ 5 / Cooling with ice View Scheme

1: With chlorosulfonic acid in dichloromethane T=20°C; 2 h; Cooling with ice; 2: With sodium carbonate; sodium hydroxide in dichloromethane; water pH=~ 6 - ~ 11;