1: With triethylamine in methanol
21 h; Heating / reflux;
2: With sodium tetrahydroborate in methanol
T=20°C; 6 h;
3: With sodium hydrogencarbonate in methanol; water
参考文献
ACTELION PHARMACEUTICALS LTD.
Patent: US2008/76762 A1, 2008 ;
Location in patent: Page/Page column 38-39; 54-55 ;
US 20080076762 A1
Rtishchev, N. I.; Kvitko, I. Ya.; Nagorskaya, L. P.; El'tsov, A. V.
Russian Journal of General Chemistry, 1993 , vol. 63, # 2.2 p. 303 - 309
Zhurnal Obshchei Khimii, 1993 , vol. 63, # 2 p. 429 - 438
1: H2O / 0.5 h / Ambient temperature
2: 60 percent / NaH (50percent in oil) / dimethylformamide / 0.17 h / 0 °C
3: 20 percent / 10percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature
View Scheme
参考文献
Higashino, Takeo; Matsushita, Yasuhiko; Takemoto, Masumi; Hayashi, Eisaku
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 11 p. 3951 - 3958
