3-马来酰亚胺基丙酸羟基琥珀酰亚胺酯合成路线 （共 8 条）
反应条件
1: maleic anhydride; 3-aminopropionic acid in acetonitrile T=70°C; Inert atmosphere; 2: 1-hydroxy-pyrrolidine-2,5-dione With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in acetonitrile T=0 - 70°C;
参考文献
CYTOS BIOTECHNOLOGY AG; WOOD, Andrew; SMITH, Helen, Kathryn; WILMSHURST, Martin, Philip; VAN, Son Thanh
Patent: WO2011/23680 A2, 2011 ;
Location in patent: Page/Page column 13-14 ;
反应条件
HOBt-6-carboxamidomethyl polystyrene; dacarbazine 1.) CH2Cl2, 25 deg C, 1 h; 2.) CH2Cl2, 25 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 39, # 11 p. 1321 - 1324
反应条件
sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; water
反应条件
2,4,6-trimethyl-pyridine in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Paterson, Michael J.; Eggleston, Ian M.
Synthetic Communications, 2008 , vol. 38, # 2 p. 303 - 308
反应条件
1-hydroxy-pyrrolidine-2,5-dione in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Song, Hong Y.; Ngai, Mun H.; Song, Zhen Y.; MacAry, Paul A.; Hobley, Jonathan; Lear, Martin J.
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 17 p. 3400 - 3406
反应条件
dicyclohexyl-carbodiimide in tetrahydrofuran; N,N-dimethyl-formamide 1.) -15 deg C, 2 h; 2.) r. t., 3 h;
参考文献
Augustin, Manfred; Mueller, Wolfgang
Journal fuer Praktische Chemie (Leipzig), 1985 , vol. 327, # 5 p. 789 - 798
反应条件
1: 12 percent / Et3N / toluene / 4 h / Heating 2: DCC / CH2Cl2 / 0.33 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 21 p. 6400 - 6407
反应条件
1: in acetonitrile T=70°C; Inert atmosphere; 2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in acetonitrile T=0 - 21°C;
参考文献
WO2011/23680 A2, ;
Page/Page column 14-15 ;
