2-(4-羟基苯基)-2-甲基丙腈合成路线 （共 8 条）
参考文献
Joensson
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 1203,1207
Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 210,214
反应条件
1: With boron tribromide in dichloromethane
T=-78 - 20°C; 3.5 h; Cooling with acetone-dry ice;
2: With water in dichloromethane
T=0°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/26305 A1, 2004 ;
Location in patent: Page/Page column 109-110 ;
WO 2004/026305 A1
反应条件
triethylamine tris(hydrogen fluoride) in acetonitrile
T=23°C; 3 h;
参考文献
MERCK and CO., INC.
Patent: WO2009/140163 A1, 2009 ;
Location in patent: Page/Page column 36 ;
WO 2009/140163 A1
反应条件
sodium hydroxide in chloroform; acetone
参考文献
The Dow Chemical Company
Patent: US4916251 A1, 1990 ;
参考文献
The Dow Chemical Company
Patent: US4806673 A1, 1989 ;
反应条件
1: aqueous methanol. KOH
2: aqueous-alcohol. KOH
View Scheme
参考文献
Joensson
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 1203,1207
Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 210,214
参考文献
Joensson
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 1203,1207
Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 210,214
反应条件
1: aqueous methanol. KOH
2: LiAlH4
View Scheme
参考文献
Joensson
Acta Chemica Scandinavica (1947-1973), 1954 , vol. 8, p. 1203,1207
Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 210,214
