4-硝基-3-[(1-氧代辛基)氧基]苯甲酸合成路线 （共 7 条）
反应条件
[45Ca]-Calcium cation; Agkistrodon piscivorus D-49 ph-lipase A2 in water; acetonitrile T=37°C; pH=7.0; effect of substrate enzime and Ca2+ concentration; Rate constant;
参考文献
Presenz
Pharmazie, 1996 , vol. 51, # 10 p. 755 - 758
反应条件
[45Ca]-Calcium cation; Agkistrodon piscivorus D-49 ph-lipase A2 in water; acetonitrile T=37°C; pH=7.0; effect of substrate enzime and Ca2+ concentration; Rate constant;
参考文献
Presenz
Pharmazie, 1996 , vol. 51, # 10 p. 755 - 758
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran
0 deg C then r.t., overnight;
参考文献
Cho, Wonhwa; Markowitz, Michael A.; Kezdy, Ferenc J.
Journal of the American Chemical Society, 1988 , vol. 110, # 15 p. 5166 - 5171
反应条件
4-methyl-morpholine; isobutyl chloroformate
1.) THF, 0 deg C, 30 min; 2.) THF, r.t., overnight; Multistep reaction. Yields of byproduct given;
参考文献
Cho, Wonhwa; Markowitz, Michael A.; Kezdy, Ferenc J.
Journal of the American Chemical Society, 1988 , vol. 110, # 15 p. 5166 - 5171
反应条件
4-methyl-morpholine; isobutyl chloroformate
1.) THF, 0 deg C, 30 min; THF, r.t., overnight; Yield given. Multistep reaction;
参考文献
Cho, Wonhwa; Markowitz, Michael A.; Kezdy, Ferenc J.
Journal of the American Chemical Society, 1988 , vol. 110, # 15 p. 5166 - 5171
反应条件
1: tris(hydroxymethyl)methylamine hydrochloride; sodium chloride; calcium chloride / water; acetonitrile / 96 h / 25 °C / pH 8 / Enzymatic reaction
2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Pirolla, Renan A. S.; Baldasso, Paulo A.; Marangoni, Sergio; Moran, Paulo J. S.; Rodrigues, Jose Augusto R.
Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 2 p. 300 - 307
反应条件
chloroformic acid ethyl ester; triethylamine
1.) toluene, one-half hour, 0 deg C, 2.) acetone, overnight, 25 deg C; Yield given. Multistep reaction;
参考文献
Markowitz, Michael A.; Seykora, John T.; Kezdy, F. J.
Bulletin des Societes Chimiques Belges, 1985 , vol. 94, # 11-12 p. 1033 - 1038
