5-甲基-2,2'-联吡啶合成路线 （共 33 条）
反应条件
potassium phosphate; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=100°C; Further byproducts given;
参考文献
Fuller, Amelia A.; Hester, Heidi R.; Salo, Eric V.; Stevens, Erland P.
Tetrahedron Letters, 2003 , vol. 44, # 14 p. 2935 - 2938
反应条件
nickel(II) dibromide hydrate; sodium iodide in N,N-dimethyl-formamide
T=20°C; Electrochemical reactionInert atmosphere;
参考文献
Oliveira, Jadson L.; Silva, Maria J.; Florencio, Tupolevck; Urgin, Karne; Sengmany, Stephane; Leonel, Eric; Nedelec, Jean-Yves; Navarro, Marcelo
Tetrahedron, 2012 , vol. 68, # 10 p. 2383 - 2390
反应条件
1: 2-bromo-pyridine With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78°C;
2: With zinc(II) chloride in tetrahydrofuran; pentane
T=20°C;
3: 5-methyl-2-chloro-pyridine With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tri-tert-butyl phosphine in tetrahydrofuran; pentane
24 h; Heating;
参考文献
Luetzen, Arne; Hapke, Marko
European Journal of Organic Chemistry, 2002 , # 14 p. 2292 - 2297
反应条件
nickel(II) dibromide hydrate; sodium iodide in N,N-dimethyl-formamide
T=20°C; Electrochemical reactionInert atmosphere;
参考文献
Oliveira, Jadson L.; Silva, Maria J.; Florencio, Tupolevck; Urgin, Karne; Sengmany, Stephane; Leonel, Eric; Nedelec, Jean-Yves; Navarro, Marcelo
Tetrahedron, 2012 , vol. 68, # 10 p. 2383 - 2390
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=20°C; Negishi reaction; 24 h;
参考文献
Fang, Yuan-Qing; Hanan, Garry S.
Synlett, 2003 , # 6 p. 852 - 854
反应条件
bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=110°C; Stille cross-coupling; 18 h; Inert atmosphere;
参考文献
Verniest, Guido; Wang, Xingpo; De Kimpe, Norbert; Padwa, Albert
Journal of Organic Chemistry, 2010 , vol. 75, # 2 p. 424 - 433
反应条件
nickel(II) dibromide hydrate; sodium iodide in N,N-dimethyl-formamide
T=20°C; Electrochemical reactionInert atmosphere;
参考文献
Oliveira, Jadson L.; Silva, Maria J.; Florencio, Tupolevck; Urgin, Karne; Sengmany, Stephane; Leonel, Eric; Nedelec, Jean-Yves; Navarro, Marcelo
Tetrahedron, 2012 , vol. 68, # 10 p. 2383 - 2390
反应条件
nickel(II) dibromide hydrate; sodium iodide in N,N-dimethyl-formamide
T=20°C; Electrochemical reactionInert atmosphere;
参考文献
Oliveira, Jadson L.; Silva, Maria J.; Florencio, Tupolevck; Urgin, Karne; Sengmany, Stephane; Leonel, Eric; Nedelec, Jean-Yves; Navarro, Marcelo
Tetrahedron, 2012 , vol. 68, # 10 p. 2383 - 2390
反应条件
bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=110°C; Stille cross-coupling; 18 h;
参考文献
Verniest, Guido; Wang, Xingpo; De Kimpe, Norbert; Padwa, Albert
Journal of Organic Chemistry, 2010 , vol. 75, # 2 p. 424 - 433
反应条件
bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=110°C; Stille cross-coupling; 18 h;
参考文献
Verniest, Guido; Wang, Xingpo; De Kimpe, Norbert; Padwa, Albert
Journal of Organic Chemistry, 2010 , vol. 75, # 2 p. 424 - 433
