N-(4-甲氧基苯基)-3-吡啶胺合成路线 （共 8 条）
反应条件
[(CyPF-tBu)PdCl2]; sodium t-butanolate in ethylene glycol dimethyl ether
T=110°C; 24 h; Inert atmosphereSealed vial;
参考文献
Shen, Qilong; Hartwig, John F.
Organic Letters, 2008 , vol. 10, # 18 p. 4109 - 4112
反应条件
sodium t-butanolate; palladium diacetate; CyPF-t-Bu in ethylene glycol dimethyl ether
T=100°C; 24 h;
参考文献
Shen, Qilong; Ogata, Tokutaro; Hartwig, John F.
Journal of the American Chemical Society, 2008 , vol. 130, # 20 p. 6586 - 6596
反应条件
tris-(dibenzylideneacetone)dipalladium(0); phenolated sodium; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane
T=80°C; 6 h;
参考文献
Mazu, Tryphon K.; Etukala, Jagan R.; Jacob, Melissa R.; Khan, Shabana I.; Walker, Larry A.; Ablordeppey, Seth Y.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2378 - 2385
反应条件
[(CyPF-tBu)PdCl2]; sodium t-butanolate in ethylene glycol dimethyl ether
T=110°C; 36 h; Inert atmosphereSealed vial;
参考文献
Shen, Qilong; Hartwig, John F.
Organic Letters, 2008 , vol. 10, # 18 p. 4109 - 4112
反应条件
CyPF-t-Bu; Pd[P(o-tol)3]2; sodium t-butanolate in toluene
T=25°C; 48 h; Inert atmosphere;
参考文献
Ogata, Tokutaro; Hartwig, John F.
Journal of the American Chemical Society, 2008 , vol. 130, # 42 p. 13848 - 13849
反应条件
copper diacetate; triethylamine in dichloromethane
T=20°C; Molecular sieve;
参考文献
Mazu, Tryphon K.; Etukala, Jagan R.; Zhu, Xue Y.; Jacob, Melissa R.; Khan, Shabana I.; Walker, Larry A.; Ablordeppey, Seth Y.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 524 - 533
反应条件
1: potassium carbonate / dichloromethane / 0 - 20 °C
2: potassium carbonate / acetonitrile / 80 °C
3: caesium carbonate / N,N-dimethyl-formamide / 120 °C
View Scheme
参考文献
Xia, Shuai; Wang, Li-Ying; Sun, Heng-Zhi; Yue, Huan; Wang, Xiu-Hua; Tan, Jia-Lian; Wang, Yin; Hou, Di; He, Xiao-Yan; Mun, Ki-Cheol; Kumar, B. Prem; Zuo, Hua; Shin, Dong-Soo
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 2 p. 394 - 398
反应条件
1: potassium carbonate / acetonitrile / 80 °C
2: caesium carbonate / N,N-dimethyl-formamide / 120 °C
View Scheme
参考文献
Xia, Shuai; Wang, Li-Ying; Sun, Heng-Zhi; Yue, Huan; Wang, Xiu-Hua; Tan, Jia-Lian; Wang, Yin; Hou, Di; He, Xiao-Yan; Mun, Ki-Cheol; Kumar, B. Prem; Zuo, Hua; Shin, Dong-Soo
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 2 p. 394 - 398
