反应条件
1: 1.) n-butyllithium, diisopropylamine / 1.) hexane, THF, -78 deg C, 15 min, 2.) THF, -78 deg C to 0 deg C, 1h
2: p-TSA, MgSO4 / toluene; CHCl3 / 3 h / 70 °C
3: H2 / Lindlar / toluene; CHCl3 / 12 h / 760 Torr
4: tert-butylamine-borane complex / CH2Cl2 / 1 h / Heating
5: 86 percent / pyridine, 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 0.2 h / 0 °C
6: 2,6-di-tert-butyl-4-methylpyridine / CH2Cl2 / 1.) room temp., overnight, 2.) reflux, 30 min
7: 94 percent / tributylamine, 98percent formic acid / Pd(OAc)2(Ph3P)2 / dimethylformamide / 0.5 h / 70 °C
8: K2CO3 / CH2Cl2; methanol / 0.08 h / 25 °C
9: bis<α,α-bis(trifluoromethyl)benzenemethanolato>diphenylsulfur / CH2Cl2 / 0.25 h / 0 °C
10: 96 percent / NaOMe / toluene; methanol / 12 h / 25 °C
View Scheme
参考文献
Dolle; Schmidt; Erhard; Kruse
Journal of the American Chemical Society, 1989 , vol. 111, # 1 p. 278 - 284
