苯基(2-甲基-1-丙烯基)甲酮合成路线 （共 92 条）
反应条件
1: 1.) (i-Pr)2NH, BuLi / 1) THF, hexane, HMPA, -78 deg C, 12.5 min; 2) THF, hexane, HMPA, -78 deg C --> rt, 30 min
2: 1.) TiCl4 / 1) CH2Cl2, -78 deg C, 1 min; 2) CH2Cl2, -78 deg C, 3 h
3: Et3N / CH2Cl2 / 1) 0 deg C, 10 min; 2) 0 deg C --> rt, 1 h
4: 70 percent / DBU / benzene / 1.5 h / Ambient temperature
View Scheme
参考文献
Otera, Junzo; Fujita, Yukihiro; Sakuta, Nobuyuki; Fujita, Morifumi; Fukuzumi, Shunichi
Journal of Organic Chemistry, 1996 , vol. 61, # 9 p. 2951 - 2962
反应条件
tris-(dibenzylideneacetone)dipalladium(0); tris(4-methylphenyl)-phosphine in 1,3,5-trimethyl-benzene
T=150°C; 12 h; Inert atmosphere;
参考文献
Rodriguez, Nuria; Manjolinho, Filipe; Gruenberg, Matthias F.; Goossen, Lukas J.
Chemistry - A European Journal, 2011 , vol. 17, # 49 p. 13688 - 13691
反应条件
copper(l) iodide; methyllithium
T=-60°C;
参考文献
Chuit,C. et al.
Tetrahedron, 1979 , vol. 35, p. 2645 - 2653
反应条件
1: tetrahydrofuran; hexamethylphosphoric acid triamide
2: HgCl2, CdCO3, H2O
View Scheme
参考文献
Donaldson; Hossain
Tetrahedron Letters, 1992 , vol. 33, # 29 p. 4107 - 4110
反应条件
1: 81 percent / Mg / tetrahydrofuran
2: 1) NaH / 1) hexamethylphosphoric triamide, 20 deg C 2) 80 deg C, 2 h
View Scheme
参考文献
Snowden, Roger L.; Muller, Bernard L.; Schulte-Elte, Karl H.
Tetrahedron Letters, 1982 , vol. 23, # 3 p. 335 - 338
反应条件
1: N-chloro-succinimide / CCl4
2: (i) NaOMe, MeOH, (ii) aq. HCl
View Scheme
参考文献
De Kimpe,N. et al.
Tetrahedron, 1979 , vol. 35, p. 789 - 798
反应条件
(i) Fe2(CO)9, (ii) /BRN= 471389/, AlCl3; Multistep reaction;
参考文献
Ehrlich,K.; Emerson,G.F.
Journal of the American Chemical Society, 1972 , vol. 94, # 7 p. 2464 - 2470
反应条件
1: 1.) butylamine / 1.) ethanol, RT, 2 d, 2.) benzene, heated, 2 h
2: 38 percent Chromat. / benzene / 3.5 h / Irradiation
View Scheme
参考文献
Grant, Richard D.; Pinhey, John T.; Rizzardo, Ezio; Smith, Geoffrey C.
Australian Journal of Chemistry, 1985 , vol. 38, # 10 p. 1505 - 1519
反应条件
in tetrahydrofuran; diethyl ether
4 h; Ambient temperature;
参考文献
Balu; Bhat; Ila; Junjappa
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1991 , vol. 30, # 2 p. 250 - 255
反应条件
[Mn(pic)3] in N,N-dimethyl-formamide
24 h; Ambient temperature;
参考文献
Narasaka, Koichi; Iwakura, Kazunori; Okauchi, Tatsuo
Chemistry Letters, 1991 , # 3 p. 423 - 426
