反应条件
1: 2-amino-1,3,5-thiadiazole; 2,4-di-(methoxy)-benzaldehyde With [TiCl(isopropoxy)3] in dichloromethane 0.75 h; 2: sodium tris(acetoxy)borohydride in dichloromethane T=20 - 34°C; 2 h;
参考文献
AMGEN INC.; BOEZIO, Christiane; BOEZIO, Alessandro; BREGMAN, Howard; CHAKKA, Nagasree; COATS, James R.; COPELAND, Katrina W.; DIMAURO, Erin F.; DINEEN, Thomas; GAO, Hua; LA, Daniel; MARX, Isaac E.; NGUYEN, Hanh Nho; PETERSON, Emily Anne; WEISS, Matthew
Patent: WO2013/122897 A1, 2013 ;
Location in patent: Page/Page column 63; 64 ;