3-氯-1,2-苯并异噻唑-1,1-二氧化物合成路线 （共 29 条）
反应条件
triethylamine in toluene Heating;
参考文献
Brigas; Johnstone
Tetrahedron Letters, 1990 , vol. 31, # 40 p. 5789 - 5790
反应条件
1: 60 percent 2: aq. H2O2, K2CO3, p-tolyl methyl sulfide / methanol 3: 45 percent / tetrahydrofuran / 5 h / -78 °C View Scheme
参考文献
Davis; Towson; Vashi; ThimmaReddy; McCauley Jr.; Harakal; Gosciniak
Journal of Organic Chemistry, 1990 , vol. 55, # 4 p. 1254 - 1261
反应条件
phosphorus pentachloride in chlorobenzene
T=10 - 130°C; 3 h;
参考文献
KOREA UNITED PHARM, INC.
Patent: WO2004/7518 A1, 2004 ;
Location in patent: Page 17 ;
反应条件
thionyl chloride in N,N-dimethyl-formamide
48 h; Heating;
参考文献
Differding, Edmond; Lang, Robert W.
Helvetica Chimica Acta, 1989 , vol. 72, p. 1248 - 1252
参考文献
Novo Nordisk A/S; Ontogen Corporation
Patent: US6410556 B1, 2002 ;
反应条件
N,N-dimethyl-formamide in 1,4-dioxane
Reflux;
参考文献
Haffner, Curt D.; Thomson, Stephen A.; Guo, Yu; Petrov, Kimberly; Larkin, Andrew; Banker, Pierette; Schaaf, Gregory; Dickerson, Scott; Gobel, Jeff; Gillie, Dan; Condreay, J. Patrick; Poole, Chuck; Carpenter, Tiffany; Ulrich, John
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 6989 - 6992
反应条件
1: 34 percent / Et3N / dioxane / Heating
2: 40 percent / aq. NaOH / acetone / 6 h / cooling
View Scheme
参考文献
Rode, Haridas B.; Sprang; Besch; Loose; Otto, Hans-Hartwig
Pharmazie, 2005 , vol. 60, # 10 p. 723 - 731
反应条件
1: 66 percent / triethylamine / acetonitrile / 0 - 5 °C
2: 38 percent / triethylamine, p-toluenesulfinic acid / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Noguchi; Isoda; Kuroki; Furukawa
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1646 - 1652
参考文献
Whitehead,C.W.; Traverso,J.J.
Journal of Organic Chemistry, 1960 , vol. 25, p. 413 - 416
反应条件
in tetrahydrofuran
T=20°C; 1.5 h;
参考文献
Brigas, Amadeu F.; Clegg, William; Dillon, Christopher J.; Fonseca, Custodia F.C.; Johnstone, Robert A.W.
Journal of the Chemical Society. Perkin Transactions 2, 2001 , # 8 p. 1315 - 1324
