N-叔丁氧羰基-3-氨基吡啶合成路线 （共 23 条）
反应条件
1: [3H]-Nicotinic acid With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine in toluene T=20°C; 0.5 h; 2: tert-butyl alcohol in toluene T=80°C; 6 h;
参考文献
EP2274983 A1, ;
Page/Page column 127-128 ;
反应条件
1: pyridin-3-ylamine With sodium hexamethyldisilazane in tetrahydrofuran 0.25 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran 15 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/49604 A2, 2005 ;
Location in patent: Page/Page column 36-37 ;
WO 2005/049604 A2
反应条件
1: pyridin-3-ylamine With sodium hexamethyldisilazane in tetrahydrofuran 0.5 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran 3 h;
参考文献
ABBOTT LABORATORIES; ABBOTT GMBH and CO.KG; MARING, Clarence J.; PRATT, John K.; CARROLL, William A.; LIU, Dachun; BETEBENNER, David A.; HUTCHINSON, Douglas K.; TUFANO, Michael D.; ROCKWAY, Todd W.; SCHOEN, Uwe; PAHL, Axel; WITTE, Adreas
Patent: WO2012/87833 A1, 2012 ;
Location in patent: Page/Page column 148 ;
WO 2012/087833 A1
反应条件
cBRIDP; bis(η3-allyl-μ-chloropalladium(II)); sodium t-butanolate in water T=50°C; 24 h; Inert atmosphereGreen chemistry;
参考文献
Isley, Nicholas A.; Dobarco, Sebastian; Lipshutz, Bruce H.
Green Chemistry, 2014 , vol. 16, # 3 p. 1480 - 1488
反应条件
1: pyridin-3-ylamine With sodium hexamethyldisilazane in tetrahydrofuran T=20°C; 0.416667 h; 2: carbonic acid di-tert-butyl ester in tetrahydrofuran T=20°C; 3.16667 h;
参考文献
EP1452525 A1, ;
Page 20-21 ;
反应条件
lead(IV) acetate in tetrachloromethane 0.25 h; Heating;
参考文献
Leardini, Rino; Zanardi, Giuseppe
Synthesis, 1982 , # 3 p. 225 - 227
反应条件
palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in 1,4-dioxane T=100°C; 24 h;
参考文献
Qin, Lijin; Cui, Hongmeng; Zou, Dapeng; Li, Jingya; Wu, Yangjie; Zhu, Zhiwu; Wu, Yusheng
Tetrahedron Letters, 2010 , vol. 51, # 33 p. 4445 - 4448
反应条件
lead(IV) acetate 2 h; Heating;
参考文献
Venuti, Michael C.; Stephenson, Robert A.; Alvarez, Robert; Bruno, John J.; Strosberg, Arthur M.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2136 - 2145
反应条件
in toluene 1 h; Heating; Yield given. Yields of byproduct given;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 24, # 11 p. 2210 - 2211
Zhurnal Organicheskoi Khimii, , vol. 24, # 11 p. 2450 - 2451
反应条件
silica gel in dichloromethane 0.05 h; Irradiation;
参考文献
Siro, Jorge G.; Martin, Justina; Garcia-Navio, Jose L.; Remuinan, Modesto J.; Vaquero, Juan J.
Synlett, 1998 , # 2 p. 147 - 148
