1-(2,2-二氟-1-苯基乙烯基)-4-氟苯合成路线 （共 35 条）
反应条件
tributylphosphine in N,N-dimethyl-formamide
参考文献
Fuqua,S.A. et al.
Journal of Organic Chemistry, 1965 , vol. 30, p. 2543 - 2545
反应条件
benzophenone in N,N-dimethyl-formamide
参考文献
Fuqua,S.A. et al.
Journal of Organic Chemistry, 1965 , vol. 30, p. 2543 - 2545
参考文献
Dear,R.E.A. et al.
Tetrahedron, 1971 , vol. 27, p. 3345 - 3355
反应条件
1: 71 percent / m-chloroperbenzoic acid / tetrahydrofuran / -78 - 20 °C
2: 80 percent / 0.05 Torr / Pyrolysis
View Scheme
参考文献
Pohmakotr, Manat; Boonkitpattarakul, Kanhokthron; Ieawsuwan, Winai; Jarussophon, Suwatchai; Duangdee, Nongnaphat; Tuchinda, Patoomratana; Reutrakul, Vichai
Tetrahedron, 2006 , vol. 62, # 25 p. 5973 - 5985
反应条件
1: 33 percent / TBAF / tetrahydrofuran / -78 - 20 °C
2: 71 percent / m-chloroperbenzoic acid / tetrahydrofuran / -78 - 20 °C
3: 80 percent / 0.05 Torr / Pyrolysis
View Scheme
参考文献
Pohmakotr, Manat; Boonkitpattarakul, Kanhokthron; Ieawsuwan, Winai; Jarussophon, Suwatchai; Duangdee, Nongnaphat; Tuchinda, Patoomratana; Reutrakul, Vichai
Tetrahedron, 2006 , vol. 62, # 25 p. 5973 - 5985
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / |Inert atmosphere
1.2: -78 - 20 °C / |Inert atmosphere
2.1: bis-triphenylphosphine-palladium(II) chloride; caesium carbonate / methanol / 22 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Kim, Ju Hee; Choi, Su Jeong; Jeong, In Howa
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 2470 - 2475
反应条件
1: magnesium sulfate; manganese(IV) oxide / dichloromethane / 0 - 20 °C
2: copper(l) iodide; cesium fluoride / 1-methyl-pyrrolidin-2-one; 1,4-dioxane / 10 h / 20 °C / |Glovebox
View Scheme
参考文献
Hu, Mingyou; He, Zhengbiao; Gao, Bing; Li, Lingchun; Ni, Chuanfa; Hu, Jinbo
Journal of the American Chemical Society, 2013 , vol. 135, # 46 p. 17302 - 17305
反应条件
1.1: hydrazine hydrate; acetic acid / ethanol / |Reflux
2.1: magnesium sulfate; manganese(IV) oxide / dichloromethane / 0 - 20 °C
3.1: copper(l) iodide; cesium fluoride / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C / |Glovebox; |Schlenk technique
3.2: 0.08 h / |Glovebox; |Schlenk technique
View Scheme
参考文献
Hu, Mingyou; He, Zhengbiao; Gao, Bing; Li, Lingchun; Ni, Chuanfa; Hu, Jinbo
Journal of the American Chemical Society, 2013 , vol. 135, # 46 p. 17302 - 17305
反应条件
1.1: magnesium sulfate; manganese(IV) oxide / dichloromethane / 0 - 20 °C
2.1: copper(l) iodide; cesium fluoride / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C / |Glovebox; |Schlenk technique
2.2: 0.08 h / |Glovebox; |Schlenk technique
View Scheme
参考文献
Hu, Mingyou; He, Zhengbiao; Gao, Bing; Li, Lingchun; Ni, Chuanfa; Hu, Jinbo
Journal of the American Chemical Society, 2013 , vol. 135, # 46 p. 17302 - 17305
反应条件
methyllithium
1.) ether, THF 0 deg C, 1h RT, 2.) 72h RT; Yield given. Multistep reaction;
参考文献
Wheaton, Gregory A.; Burton, Donald J.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 917 - 927
