5-甲基-4-硝基噻吩-2-羧酸甲酯合成路线 （共 14 条）
反应条件
1.1: hydrogen / Raney Ni / tetrahydrofuran; methanol / 36 h / 20 °C / 760.05 Torr
2.1: potassium acetate / toluene / 3 h / 100 °C
2.2: 100 °C
View Scheme
参考文献
SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: US2012/245178 A1, 2012 ;
US 20120245178 A1
反应条件
1.1: hydrogen / Raney Ni / tetrahydrofuran; methanol / 36 h / 20 °C / 760.05 Torr
2.1: potassium acetate / toluene / 3 h / 100 °C
2.2: 100 °C
3.1: sodium tetrahydroborate / methanol / 0.5 h / 20 °C
3.2: 0.5 h / 0 °C
View Scheme
参考文献
SU, Wei-Guo; JIA, Hong; DAI, Guangxiu
Patent: US2012/245178 A1, 2012 ;
US 20120245178 A1
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate
P=2585.81 Torr;
参考文献
AVENTIS PHARMACEUTICALS INC.
Patent: WO2005/26175 A1, 2005 ;
Location in patent: Page/Page column 75-76 ;
WO 2005/026175 A1
参考文献
Sorenson, Roderick Joseph
Patent: US2003/87924 A1, 2003 ;
US 20030087924 A1
