2-(1,3-二氧杂烷-2-基)吡啶合成路线 （共 10 条）
反应条件
in sulfolane; ethyl acetate
参考文献
Sterling Winthrop Inc.
Patent: US5554620 A1, 1996 ;
参考文献
Bradsher,C.K. et al.
Journal of Heterocyclic Chemistry, 1965 , vol. 2, p. 228 - 230
反应条件
ammonium nitrate; Montmorillonite-K10 deprotection; 0.05 h; microwave irradiation;
参考文献
Meshram; Sumithra; Reddy; Ganesh; Yadav
Synthetic Communications, 1999 , vol. 29, # 16 p. 2807 - 2815
反应条件
in diethyl ether 1.) 15 deg C, 10 h, 2.) 5 deg C, overnight;
参考文献
Benito, Y.; Canoira, L.; Martinez-Lopez, N.; Rodriguez, J. G.; Temprano, F.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 623 - 628
反应条件
potassium tert-butylate in tetrahydrofuran; N,N-dimethyl-formamide
T=-60°C; 1.5 h;
参考文献
Barbasiewicz, Michal; Makosza, Mieczyslaw
Organic Letters, 2006 , vol. 8, # 17 p. 3745 - 3748
反应条件
toluene-4-sulfonic acid in benzene
HeatingDean-Stark apparatus;
参考文献
Hobson, Stephen T.; Boecker, Joseph D.; Gifford, James H.; Nohe, Tara L.; Wierks, Carl H.
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 2 p. 277 - 282
反应条件
p-toluenesulfonic acid monohydrate in ethylene glycol; toluene
参考文献
Sterling Winthrop Inc.
Patent: US5554620 A1, 1996 ;
反应条件
tert.-butylhydroperoxide; sulfuric acid; iron(II) sulfate in water
T=5 - 7°C; pH 4.5-5; Further byproducts given;
参考文献
Zorin, V. V.; Zelechonok, Yu. B.; Zlot'skii, S. S.; Rakhmankulov, D. L.
Journal of Organic Chemistry USSR (English Translation), 1985 , vol. 21, # 1 p. 174 - 176
Zhurnal Organicheskoi Khimii, 1985 , vol. 21, # 1 p. 193 - 196
反应条件
1: acetone / Heating
2: HBr (48percent) / 100 °C
View Scheme
参考文献
Mukerjee, Y. N.; Gaur, S. P.; Jain, P. C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 985 - 987
反应条件
1: 85 percent / diethyl ether / 10 h / 10 - 15 °C
2: 1. NaBH4; 2. hydrogen / PtO2 / 1. water, r.t., 30min.; 2. methanol, 40 psi, r.t., 4h
3: 65 percent / 10percent aq. sulfuric acid / 40 h / 80 °C
View Scheme
参考文献
Benito, Y.; Canoira, L.; Martinez-Lopez, N.; Rodriguez, J. G.; Temprano, F.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 623 - 628
