1: 2-propenylcarboxylic acid With pyridine; pivaloyl chloride in benzene T=0°C; 0.25 h; 2: 3-amino-pyridine-2-carboxylic acid thiazol-2-ylamide in N,N-dimethyl-formamide; benzene T=20°C; 8 h;

1.1: 49 percent / Et3N / dimethylformamide / 40 - 50 °C 2.1: 44 percent / HOBT; DCC / dimethylformamide / 24 h / 20 °C 3.1: 91 percent / TFA / CH2Cl2 / 4 h / -10 - 20 °C 4.1: pyridine; Me3CCOCl / benzene / 0.25 h / 0 °C 4.2: 76 percent / benzene; dimethylformamide / 8 h / 20 °C View Scheme

1.1: 44 percent / HOBT; DCC / dimethylformamide / 24 h / 20 °C 2.1: 91 percent / TFA / CH2Cl2 / 4 h / -10 - 20 °C 3.1: pyridine; Me3CCOCl / benzene / 0.25 h / 0 °C 3.2: 76 percent / benzene; dimethylformamide / 8 h / 20 °C View Scheme

1.1: 91 percent / TFA / CH2Cl2 / 4 h / -10 - 20 °C 2.1: pyridine; Me3CCOCl / benzene / 0.25 h / 0 °C 2.2: 76 percent / benzene; dimethylformamide / 8 h / 20 °C View Scheme