3’-甲基联苯-4-甲酸合成路线 （共 11 条）
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Wyeth
Patent: US2003/18024 A1, 2003 ;
反应条件
4C3H6N6*Pd(2+)*2C2H3O2(1-); sodium carbonate in water T=80°C; Suzuki-Miyaura Coupling; 2 h; Green chemistry;
参考文献
Edwards, Grant A.; Trafford, Mitchell A.; Hamilton, Alaina E.; Buxton, Audrey M.; Bardeaux, Matthew C.; Chalker, Justin M.
Journal of Organic Chemistry, 2014 , vol. 79, # 5 p. 2094 - 2104
反应条件
tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=80°C; 48 h;
参考文献
Homsi, Fadi; Nozaki, Kyoko; Hiyama, Tamejiro
Tetrahedron Letters, 2000 , vol. 41, # 31 p. 5869 - 5872
反应条件
1.1: Mg / tetrahydrofuran 1.2: 72 percent / tetrahydrofuran / 20 °C 2.1: 94 percent / KF; tri(2-furyl)phosphine / Pd(OAc)2 / dimethylformamide / 44 h / 120 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 624, # 1-2 p. 208 - 216
反应条件
1: 87 percent / CuF2*2H2O / diethyl ether / 20 °C 2: 94 percent / TBAF / Pd(PPh3)4 / tetrahydrofuran / 48 h / 80 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 624, # 1-2 p. 208 - 216
反应条件
1: 1.) n-BuLi, 2.) ZnCl2, 3.) (Ph3P)2PdCl2, (i-Bu)2AlH 2: aq. NaOH / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 4 p. 437 - 450
反应条件
tetrakis(triphenylphosphine) palladium(0); trifluoroacetic acid; Wang resin Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 20 p. 3144 - 3150
参考文献
Chemische Berichte, , vol. 65, p. 1382,1392
反应条件
water in methanol T=30 - 50°C; ΔH(excit), ΔS(excit), log A; Rate constantThermodynamic dataKinetics;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 1 p. 35 - 38
反应条件
(i) (diazotization), (ii) /BRN= 1072099/, aq. NaOH, (iii) aq. KOH, MeOH; Multistep reaction;
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 840 - 845
