3,4-二氢-2H-菲-1-酮合成路线 （共 48 条）
反应条件
n-Butyl nitrite; potassium ethanolate in diethyl ether; ethanol
T=0°C; 12 h;
参考文献
Schoneberger; Back
Archiv der Pharmazie, 1984 , vol. 317, # 3 p. 219 - 222
反应条件
diethyl ether
anschliessend Behandeln mit Kalium-tert-pentylat in tert-Pentylalkohol und Benzol;
参考文献
Meyer; Reichstein
Pharmaceutica Acta Helvetiae, 1944 , vol. 19, p. 127,150
反应条件
1: n-butyl nitrite, EtOK / ethanol; diethyl ether / 12 h / 0 °C
2: H2, 2N HCl / 5percent Pd/BaSO4 / methanol / Ambient temperature
3: LiAlH4 / diethyl ether / 1 h / Heating
View Scheme
参考文献
Schoneberger; Back
Archiv der Pharmazie, 1984 , vol. 317, # 3 p. 219 - 222
反应条件
1: diethyl ether; benzene
2: palladium coal / 310 - 320 °C
View Scheme
参考文献
Beckwith,A.L.J.; Thompson,M.J.
Journal of the Chemical Society, 1961 , p. 73 - 80
反应条件
1: 96 percent / POCl3 / dimethylformamide / 1) 0-5 deg C, 1 h, 2) r.t., 15 h, 3) 45-50 deg C, 1 h
2: Et3N / pyridine / 1.33 h / 45 - 50 °C
3: 50percent aq. KOH / pyridine / 0.33 h / 20 °C
4: 99 percent / 5percent aq. KOH / ethanol / 5 h / Heating
5: 99 percent / copper chromite / quinoline / 5 h / Heating
6: 96 percent / DDQ / benzene / 3.5 h / Heating
View Scheme
参考文献
Kar, Gandhi K.; Karmakar, Arun C.; Ray, Jayanta K.
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 999 - 1002
参考文献
Meyer; Reichstein
Pharmaceutica Acta Helvetiae, 1944 , vol. 19, p. 127,150
反应条件
1.1: LDA / tetrahydrofuran / 2 h / -78 °C
1.2: tetrahydrofuran / 10 h / 0 - 20 °C
2.1: 58 percent / CuCl2*2H2O; Li; 4,4'-di-tert-butylbiphenyl / tetrahydrofuran / 6 h / 20 °C
View Scheme
参考文献
Yagi,H.; Jerina,D.M.
Journal of the American Chemical Society, 1975 , vol. 97, p. 3185 - 3192
反应条件
(i) NBS, PhCO3H, THF, (ii) (4-nitro-phenyl)-hydrazine, NaOAc, AcOH, (iii) H2, Raney-Ni, MeOH, THF; Multistep reaction;
参考文献
Dannenberg,H.; Meyer,E.
Chemische Berichte, 1969 , vol. 102, # 7 p. 2384 - 2391
