in ethylene glycol dimethyl ether T=20°C; 1 h;

1: 5-bromo-2-piperidin-1-yl-pyrimidine With n-butyllithium in tetrahydrofuran; hexanes T=-78 - -70°C; 1 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexanes T=-70°C; 1 h;