N-(2-吡啶基甲基)-2,5-二(2,2,2-三氟乙氧基)苯甲酰胺合成路线 （共 6 条）
参考文献
Geneva Pharmaceuticals, Inc.
Patent: US6458957 B1, 2002 ;
反应条件
triethylamine in water; benzene
反应条件
in ethyl acetate T=15 - 25°C; 1 h;
参考文献
EP1918280 A1, ;
Page/Page column 4; 7 ;
反应条件
1: 2,5-di-(2,2,2-trifluoroethoxy)benzoic acid With pivaloyl chloride; triethylamine in dichloromethane; N,N-dimethyl acetamide T=-30 - -20°C; 2: 2-Pyridinylmethylamine in dichloromethane; N,N-dimethyl acetamide T=-20°C; 2 h; 3: With sodium carbonate in dichloromethane; N,N-dimethyl acetamide; water Product distribution / selectivity;
参考文献
WO2007/3982 A1, ;
Page/Page column 7 ;
反应条件
1: 2,5-bis(2,2,2-trifluoroethoxy)-N-(pyridin-2-ylmethyl)-benzamide With hydrogen; acetic acid; palladium 10 on activated carbon; platinum on carbon T=69 - 72°C; P=2925.29 - 4425.44 Torr; 5 h; 2: With sodium hydroxide in water pH=13 - 14; 3: acetic acid in ethyl acetate T=31°C;
参考文献
"Joint Stock Company Grindeks"
Patent: EP1918280 A1, 2008 ;
Location in patent: Page/Page column 4; 8 ;
参考文献
Geneva Pharmaceuticals, Inc.
Patent: US6458957 B1, 2002 ;
