3-(1-哌啶基)苯甲酸甲酯合成路线 （共 13 条）
反应条件
1: CBr4, PPh3 / CH2Cl2 / 2 h / Ambient temperature
2: 1.) NaH, 2.) KI / 1.) DMF, RT, 10 min, 2.) DMF, 70 deg C, 4 h
3: 90 percent / borane-THF complex / tetrahydrofuran / 1 h / Heating
View Scheme
参考文献
Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341
反应条件
1: 1.) NaH, 2.) KI / 1.) DMF, RT, 10 min, 2.) DMF, 70 deg C, 4 h
2: 90 percent / borane-THF complex / tetrahydrofuran / 1 h / Heating
View Scheme
参考文献
Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341
参考文献
Quibell, Martin; Taylor, Steven; Grabowska, Urszula; Nilsson, Magnus; Morrison, Veronique
Patent: US2003/186962 A1, 2003 ;
