1-羟基-双环己基-1-甲腈合成路线 （共 8 条）
反应条件
iso-propylmagnesium bromide in tetrahydrofuran
T=-78°C; 2 h;
参考文献
Fleming, Fraser F.; Zhang, Zhiyu; Liu, Wang; Knochel, Paul
Journal of Organic Chemistry, 2005 , vol. 70, # 6 p. 2200 - 2205
反应条件
1: With magnesium chloride in dimethyl sulfoxide
T=30°C; 24 h; Inert atmosphere;
2: With hydrogenchloride in methanol; water; dimethyl sulfoxide
0.166667 h; Inert atmosphere;
参考文献
Jinzaki, Takaaki; Arakawa, Mitsuru; Kinoshita, Hidenori; Ichikawa, Junji; Miura, Katsukiyo
Organic Letters, 2013 , vol. 15, # 14 p. 3750 - 3753
反应条件
isopropylmagnesium chloride in tetrahydrofuran; diethyl ether
T=-78 - 20°C;
参考文献
Nath, Dinesh; Fleming, Fraser F.
Chemistry - A European Journal, 2013 , vol. 19, # 6 p. 2023 - 2029
反应条件
(i) LDA, THF, hexane, (ii) MoO5, Py, HMPT; Multistep reaction;
参考文献
Vedejs,E.; Telschow,J.E.
Journal of Organic Chemistry, 1976 , vol. 41, p. 740 - 741
反应条件
1: cyclohexane-1,1-dicarbonitrile With naphthalenyllithium in tetrahydrofuran
T=-40°C; 0.666667 h;
2: cyclohexanone in tetrahydrofuran
T=-40°C; 1 h;
参考文献
Tsai, Ting-Yueh; Shia, Kak-Shan; Liu, Hsing-Jang
Synlett, 2003 , # 1 p. 97 - 101
反应条件
1: caesium carbonate / tetrahydrofuran / 6 h / Reflux
2: isopropylmagnesium chloride / tetrahydrofuran; diethyl ether / -78 - 20 °C
View Scheme
参考文献
Nath, Dinesh; Fleming, Fraser F.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 49 p. 11790 - 11793
参考文献
Humphreys,D.J.; Newall,C.E.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1978 , p. 33 - 45
反应条件
1: 89 percent / NaH / tetrahydrofuran / 20 °C
2: 89 percent / lithium α-(dimethylamino)naphthalenide / tetrahydrofuran / 1.5 h / -60 °C
View Scheme
参考文献
Tsai, Ting-Yueh; Shia, Kak-Shan; Liu, Hsing-Jang
Synlett, 2003 , # 1 p. 97 - 101
