1-(1-萘基)对二氮已环合成路线 （共 10 条）
反应条件
bis (triortho-tolylphosphine)palladium(II) chloride; sodium t-butanolate in diethylene glycol dimethyl ether
T=170°C; 48 h; Inert atmosphere;
参考文献
Ghosh, Balaram; Antonio, Tamara; Zhen, Juan; Kharkar, Prashant; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 3 p. 1023 - 1037
反应条件
potassium tert-butylate; palladium diacetate in anhydrous xylene
参考文献
BASF Aktiengesellschaft
Patent: US6387912 B1, 2002 ;
反应条件
1: piperazine With [2,2']bipyridinyl; nickel diacetate; sodium hydride; 1,1-dimethylpropan-1-ol in tetrahydrofuran
T=65°C; 2 h;
2: alpha-chloronaphthalene With styrene in tetrahydrofuran
T=65°C; 5 h;
参考文献
Brenner, Eric; Schneider, Raphael; Fort, Yves
Tetrahedron, 2002 , vol. 58, # 34 p. 6913 - 6924
反应条件
Pd-C in methanol; dichloromethane
参考文献
Recordati S.A.
Patent: US2003/162777 A1, 2003 ;
US 20030162777 A1
反应条件
potassium carbonate in diethylene glycol dimethyl ether
48 h; Heating;
参考文献
Glennon, Richard A.; Slusher, R. M.; Lyon, Robert A.; Titeler, Milt; McKenney, J. D.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2375 - 2380
反应条件
sodium t-butanolate; palladium diacetate; tri-tert-butyl phosphine in o-xylene
T=120°C; Yield given;
参考文献
Nishiyama, Masakazu; Yamamoto, Toshihide; Koie, Yasuyuki
Tetrahedron Letters, 1998 , vol. 39, # 7 p. 617 - 620
反应条件
T=20 - 165°C; neat (no solvent);
参考文献
Konstantinova, Igor; Bukhryakov, Konstantin; Gezentsvey, Yuri; Krasavin, Mikhail
Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 628 - 630
反应条件
1: 65 percent / tri(o-tolyl)phosphine, bis(dibenzylideneacetone)palladium(O), sodium tert-butoxide / toluene / 19 h / 100 °C
2: 91 percent / trifluoroacetic acid / CH2Cl2 / 1 h / Ambient temperature
View Scheme
参考文献
Kerrigan, Frank; Martin, Claire; Thomas, Gerard H.
Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2219 - 2222
反应条件
sodium hydrogencarbonate
参考文献
Prelog; Blazek
Collection of Czechoslovak Chemical Communications, 1934 , vol. 6, p. 211,218
反应条件
1: triethylamine / toluene / Heating
2: H2 / Raney Ni / ethanol / Ambient temperature
View Scheme
参考文献
Saxena, Anil K.; Arunamurthy, V.; Patnaik, G. K.; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 10 p. 873 - 878
