6-甲氨基-1,3-二甲基脲嘧啶合成路线 （共 24 条）
反应条件
1: aqueous HCl; ethanol 2: Raney nickel; methanol / Hydrogenation 3: ethanol View Scheme
参考文献
Pfleiderer; Schuendehuette
Justus Liebigs Annalen der Chemie, 1958 , vol. 612, p. 158,162
反应条件
in dichloromethane 2 h; Ambient temperaturethen refluxed for 2-3 h;
参考文献
Kokel; Boussouira
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1493 - 1498
反应条件
3 h; Heating; Yields of byproduct given;
参考文献
Itoh, Tsuneo; Fujii, Ikuko; Tomii, Yasuo; Ishikawa, Ichiro; Ogura, Haruo; et al.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1453 - 1455
反应条件
1) CH2Cl2, reflux 1 h 2) irradiated 13 h in acetone; Yield given. Multistep reaction;
参考文献
Itoh, Tsuneo; Fujii, Ikuko; Tomii, Yasuo; Ishikawa, Ichiro; Ogura, Haruo; et al.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1453 - 1455
反应条件
1: 89 percent / NBS, AIBN / tetrahydrofuran / Ambient temperature 2: 47 percent / NaN3 / dimethylformamide / Ambient temperature View Scheme
参考文献
Hirota, Kosaku; Sako, Magoichi; Sajiki, Hironao
Heterocycles, 1997 , vol. 46, # 1 p. 547 - 554
反应条件
1: aqueous HCl; ethanol 2: Raney nickel; methanol / Hydrogenation 3: formic acid View Scheme
参考文献
Pfleiderer; Schuendehuette
Justus Liebigs Annalen der Chemie, 1958 , vol. 612, p. 158,162
反应条件
in dichloromethane 2 h; Ambient temperaturethen refluxed for 2-3 h;
参考文献
Kokel; Boussouira
Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 6 p. 1493 - 1498
反应条件
sodium hydrogencarbonate in ethanol
3 h; Heating;
参考文献
Reis, Lucinda V.; Lobo, Ana M.; Prabhakar, Sundaresan; Duarte, Mariana P.
European Journal of Organic Chemistry, 2003 , # 1 p. 190 - 208
反应条件
sodium hydride in tetrahydrofuran
T=0 - 20°C; 4.5 h;
参考文献
Reis, Lucinda V.; Lobo, Ana M.; Prabhakar, Sundaresan; Duarte, Mariana P.
European Journal of Organic Chemistry, 2003 , # 1 p. 190 - 208
反应条件
1: 80 percent / NaHCO3 / ethanol / 3 h / Heating
2: 95 percent / iPr2NEt / tetrahydrofuran / 2 h / 0 - 20 °C
3: 36 percent / toluene / 1 h
View Scheme
参考文献
Reis, Lucinda V.; Lobo, Ana M.; Prabhakar, Sundaresan; Duarte, Mariana P.
European Journal of Organic Chemistry, 2003 , # 1 p. 190 - 208
