1: 95 percent / thionyl chloride / 18 h / 20 °C 2: CH2Cl2 / 2 h / 20 °C 3: thionyl chloride / 1 h / 25 °C 4: tetrahydrofuran / 2 h / 20 °C 5: 88 percent / 4.5 N aq. HCl / 12 h / Heating 6: 1.) acetyl chloride / 1.) 0 deg C, 0.25 h, 2.) reflux, 4 h 7: 42.55 g / diisobutylaluminum hydride / toluene / 0.25 h / -78 - -70 °C 8: pyridinium chlorochromate / CH2Cl2 / 0.5 h / 25 °C View Scheme
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
