(3AR,4S,5R,6AS)-4-[(乙酰氧基)甲基]六氢-5-羟基-2H-环戊并[B]呋喃-2-酮合成路线 (共 8 条)
反应条件
Amberlite IR 120 resin in methanol T=70°C; 8 h;
参考文献
Toemoeskoezi, Istvan; Gruber, Lajos; Baitz-Gacs, Eszter
Tetrahedron, 1992 , vol. 48, # 47 p. 10345 - 10352
反应条件
sulfuric acid
T=75 - 80°C; 24 h;
参考文献
Toemoeskoezi, Istvan; Gruber, Lajos; Baitz-Gacs, Eszter
Tetrahedron, 1992 , vol. 48, # 47 p. 10345 - 10352
反应条件
sulfuric acid; acetic acid
T=75 - 80°C; 24 h;
参考文献
Toemoeskoezi, Istvan; Gruber, Lajos; Baitz-Gacs, Eszter
Tetrahedron, 1992 , vol. 48, # 47 p. 10345 - 10352
反应条件
in dichloromethane
3 h; Ambient temperaturelipase AK;
参考文献
Sugahara; Satoh; Yamada; Takano
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 10 p. 2758 - 2760
反应条件
sodium hydroxide; Soerensen phosphate buffer in acetone
T=36°C; 24 h; subtilisin DY; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Theil, Fritz; Schick, Hans; Nedkov, Peter; Boehme, Monika; Haefner, Barbara; Schwarz, Sigfrid
Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 6 p. 893 - 899
反应条件
sodium hydroxide; Soerensen phosphate buffer in acetone
T=36°C; 24 h; subtilisin DY; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Theil, Fritz; Schick, Hans; Nedkov, Peter; Boehme, Monika; Haefner, Barbara; Schwarz, Sigfrid
Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 6 p. 893 - 899
反应条件
triethylamine in tetrahydrofuran
T=23°C; 5 h; Lipase Amano PS; enzymatically with various lipases; regio- and enantioselective transesterifications; resolution of rac-1 into its enantiomers; Product distribution;
参考文献
Weidner, Judith; Theil, Fritz; Kunath, Annamarie; Schick, Hans
Liebigs Annalen der Chemie, 1991 , # 12 p. 1301 - 1304
反应条件
sodium hydroxide in methanol
T=36°C; 24 h; subtilisin DY, Soerensen phosphate buffer pH 7, further solvents, further enzymes; Product distribution;
参考文献
Theil, Fritz; Schick, Hans; Nedkov, Peter; Boehme, Monika; Haefner, Barbara; Schwarz, Sigfrid
Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 6 p. 893 - 899