1-(乙酰氨基)-1-苯乙烯合成路线 （共 32 条）
反应条件
chiral [2,2']-diphospholanyl-based Rh(I); hydrogen in methanol T=20°C; P=1034.3 Torr; 12 h;
参考文献
Gridnev; Yasutake; Higashi; Imamoto
Journal of the American Chemical Society, 2001 , vol. 123, # 22 p. 5268 - 5276
反应条件
lt;lt;(R,R)-1,2-bis(trans-2,5-dimethylphospholano)ethanegt;Rh(COD)gt;OTf; hydrogen in methanol T=22°C; P=3102.9 Torr; 15 h; var. rhodium chiral complexes and solvents; other aryl enamides; Product distribution;
参考文献
Hayashi, Minoru; Hashimoto, Yukihiko; Takezaki, Hiroshi; Watanabe, Yuichiro; Saigo, Kazuhiko
Tetrahedron Asymmetry, 1998 , vol. 9, # 11 p. 1863 - 1866
反应条件
hydrogen in tetrahydrofuran
参考文献
The Hong Kong Polytechnic University
Patent: US5919981 A1, 1999 ;
反应条件
18-crown-6 ether; cesium fluoride in tetrahydrofuran T=80°C; chemoselective reaction;
参考文献
Zhao, Mi-Na; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui
Chemical Communications, 2012 , vol. 48, # 65 p. 8105 - 8107
反应条件
oxygen; potassium acetate; palladium diacetate in dimethyl sulfoxide T=80°C; P=760.051 Torr; 24 h; Reagent/catalyst; regioselective reaction;
参考文献
Xu, Yun-He; He, Tao; Zhang, Qiu-Chi; Loh, Teck-Peng
Chemical Communications, 2014 , vol. 50, # 21 p. 2784 - 2786
反应条件
[Pd(CH3CN)4](BF4)2; oxygen; sodium acetate in dimethyl sulfoxide T=80°C; P=760.051 Torr; 24 h; Overall yield = 51 percent;
参考文献
Xu, Yun-He; He, Tao; Zhang, Qiu-Chi; Loh, Teck-Peng
Chemical Communications, 2014 , vol. 50, # 21 p. 2784 - 2786
反应条件
[Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; potassium iodide in 1,2-dichloro-ethane
3 h; RefluxInert atmosphere; Reagent/catalystSolventTime;
参考文献
Murugan, Kaliyappan; Huang, Da-Wei; Chien, Yu-Ting; Liu, Shiuh-Tzung
Tetrahedron, 2013 , vol. 69, # 1 p. 268 - 273
反应条件
N-ethyl-N,N-diisopropylamine; 1,1'-bis-(diphenylphosphino)ferrocene; tris(dibenzylideneacetone)dipalladium (0) in 1,4-dioxane
T=85°C; Heck coupling; 1 h;
参考文献
Hansen, Anders Lindhardt; Skrydstrup, Troels
Journal of Organic Chemistry, 2005 , vol. 70, # 15 p. 5997 - 6003
反应条件
1: acetophenone With titanium(IV) isopropylate; ammonia in methanol; toluene
0.166667 h; Inert atmosphereCooling with ice;
2: acetic anhydride With triethylamine
T=5 - 20°C;
参考文献
Reeves, Jonathan T.; Tan, Zhulin; Han, Zhengxu S.; Li, Guisheng; Zhang, Yongda; Xu, Yibo; Reeves, Diana C.; Gonnella, Nina C.; Ma, Shengli; Lee, Heewon; Lu, Bruce Z.; Senanayake, Chris H.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 6 p. 1400 - 1404
反应条件
1: NH2OH*HCl / ethanol; pyridine / 5 h / Heating
2: AcOH; TMSCl / Fe / toluene / 5 h / 70 °C
View Scheme
参考文献
Van Den Berg, Michel; Haak, Robert M.; Minnaard, Adriaan J.; De Vries, Andre H. M.; De Vries, Johannes G.; Feringa, Ben L.
Advanced Synthesis and Catalysis, 2002 , vol. 344, # 9 p. 1003 - 1007
