D-alpha-生育酚醋酸酯合成路线 （共 18 条）
反应条件
sulfuric acid T=60°C; Acetylation; KineticsEquilibrium constant; Further Variations:Temperatures;
参考文献
Pharmaceutical Chemistry Journal, , vol. 32, # 6 p. 331 - 332
反应条件
durch fraktionierte Krystallisation;
反应条件
dihydrogen peroxide; methyltrioxorhenium (VII) in ethanol; water T=25°C; 10 h;
参考文献
Saladino, Raffaele; Neri, Veronica; Farina, Angela; Crestini, Claudia; Nencioni, Lucia; Palamara, Anna Teresa
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 2 p. 321 - 331
反应条件
1: potassium hydroxide / ethanol / 1 h / 10 °C 2: anhydrous iron chloride; water 3: Pearlman's catalist; hydrogen View Scheme
参考文献
Shrader, William D.; Amagata, Akiko; Barnes, Adam; Hinman, Andrew; Jankowski, Orion; Lee, Edgar; Kheifets, Viktoria; Komatsuzaki, Ryo; Mollard, Paul; Murase, Katsuyuki; Rioux, Patrice; Wesson, Kieron; Miller, Guy
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 391 - 395
反应条件
cholesterol esterase; tris-buffer; chenodeoxycholate; dimyristoyl-phosphatidylcholine T=37°C; initial rates of the reaction; other dihydroxy and trihydroxy bile salts; also epimeric tocopheryl acetate;
参考文献
PENWEST PHARMACEUTICALS CO.; PAISLEY, Steven, D.; LEPREE, Jason, M.; HAWI, Amale; ECKHOFF, Michael
Patent: WO2011/112679 A1, 2011 ;
Location in patent: Page/Page column 23-25 ;
反应条件
dimyristoylphosphatidylcholine; Tris buffer; cholic acid sodium salt pure porcine cholesterol esterase (PCE); other bile salts, other carboxylic ester hydrolase; Rate constant;
参考文献
Zahalka; Dutton; O'Doherty; Smart; Foster; Burton; Ingold
Journal of the American Chemical Society, 1991 , vol. 113, # 7 p. 2797 - 2799
反应条件
sulfuric acid T=60°C; Hydrolysis; Equilibrium constant; Further Variations:Temperatures;
参考文献
Bulychev
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 6 p. 331 - 332
反应条件
sulfuric acid T=60°C; Hydrolysis; Equilibrium constant; Further Variations:Temperatures;
参考文献
Bulychev
Pharmaceutical Chemistry Journal, 1998 , vol. 32, # 6 p. 331 - 332
