叔丁氧基二(二甲基氨基)甲烷合成路线 （共 92 条）
参考文献
Zeneca Limited
Patent: US5684011 A1, 1997 ;
参考文献
American Cyanamid Company
Patent: US4521422 A1, 1985 ;
反应条件
in N,N-dimethyl-formamide T=140°C; 2 h;
参考文献
Klose; Schwarz
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 5 p. 1165 - 1167
反应条件
in ethanol 20 h; Heating; Yields of byproduct given;
参考文献
Mueller, Hans-Georg; Hartke, Klaus; Kaempchen, Thomas; Massa, Werner; Hahn, Friedemann
Archiv der Pharmazie (Weinheim, Germany), 1988 , vol. 321, p. 873 - 878
反应条件
1: tert-butoxy-bis-(dimethylamino)methane; 3,4-dihydronaphthalene-1(2H)-one T=90°C; 2: 1-methylguanidine hydrochloride With sodium in ethanol 70 h; Heating / reflux;
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: WO2008/83356 A1, 2008 ;
Location in patent: Page/Page column 142-143 ;
WO 2008/083356 A1
反应条件
N-methylamine hydrochloride in ethanol; water
参考文献
Eli Lilly and Company
Patent: US4152136 A1, 1979 ;
反应条件
hydrogenchloride; sodium tetrahydroborate; potassium carbonate; trichlorophosphate Yield given. Multistep reaction;
参考文献
Loegers, Michael; Overman, Larry E.; Welmaker, Gregory S.
Journal of the American Chemical Society, 1995 , vol. 117, # 36 p. 9139 - 9150
参考文献
Kantlehner, Willi; Wagner, Fritz; Bredereck, Hellmut
Liebigs Annalen der Chemie, 1980 , # 3 p. 344 - 357
参考文献
Kantlehner, Willi; Wagner, Fritz; Bredereck, Hellmut
Liebigs Annalen der Chemie, 1980 , # 3 p. 344 - 357
参考文献
Kantlehner, Willi; Wagner, Fritz; Bredereck, Hellmut
Liebigs Annalen der Chemie, 1980 , # 3 p. 344 - 357
