2-甲基-2-丙基N-[(苄氧基)羰基]-O-(2-甲基-2-丙基)-L-丝氨酸酯合成路线 （共 10 条）
反应条件
1: H2 / 5percent Pd/C / methanol 2: 1 M HCl / ethyl acetate / Ambient temperature View Scheme
参考文献
Gibson, Frank S.; Bergmeier, Stephen C.; Rapoport, Henry
Journal of Organic Chemistry, 1994 , vol. 59, # 11 p. 3216 - 3218
反应条件
nitric acid in dichloromethane T=0°C; nitrolysis; 2 h;
参考文献
Tetrahedron, , vol. 56, # 22 p. 3625 - 3633
反应条件
nitric acid in dichloromethane T=0°C; nitrolysis; 2 h;
参考文献
Tetrahedron, , vol. 56, # 22 p. 3625 - 3633
反应条件
1: Et3N / dioxane / 1.5 h / Heating 2: H2O / dioxane / Ambient temperature View Scheme
参考文献
Trzeciak, Arnold; Bannwarth, Willi
Synthesis, 1996 , # 12 p. 1433 - 1434
反应条件
sulfuric acid in dichloromethane
T=-25 - 20°C; Alkylation;
参考文献
Strazzolini, Paolo; Scuccato, Massimo; Giumanini, Angelo G.
Tetrahedron, 2000 , vol. 56, # 22 p. 3625 - 3633
反应条件
in tetrahydrofuran; dichloromethane
Ambient temperature;
参考文献
Thierry, Josiane; Yue, Chongwei; Potier, Pierre
Tetrahedron Letters, 1998 , vol. 39, # 12 p. 1557 - 1560
反应条件
1: 70 percent / 96 percent H2SO4 / CH2Cl2 / -25 - 20 °C
2: 91 percent / N2H2*H2O / ethanol / 0 - 20 °C
3: 89 percent / 100 percent HNO3 / CH2Cl2 / 2 h / 0 °C
4: 80 percent / 96 percent H2SO4 / CH2Cl2 / -25 - 20 °C
View Scheme
参考文献
Strazzolini, Paolo; Scuccato, Massimo; Giumanini, Angelo G.
Tetrahedron, 2000 , vol. 56, # 22 p. 3625 - 3633
反应条件
1: 89 percent / 100 percent HNO3 / CH2Cl2 / 2 h / 0 °C
2: 80 percent / 96 percent H2SO4 / CH2Cl2 / -25 - 20 °C
View Scheme
参考文献
Strazzolini, Paolo; Scuccato, Massimo; Giumanini, Angelo G.
Tetrahedron, 2000 , vol. 56, # 22 p. 3625 - 3633
反应条件
1: 91 percent / N2H2*H2O / ethanol / 0 - 20 °C
2: 89 percent / 100 percent HNO3 / CH2Cl2 / 2 h / 0 °C
3: 80 percent / 96 percent H2SO4 / CH2Cl2 / -25 - 20 °C
View Scheme
参考文献
Strazzolini, Paolo; Scuccato, Massimo; Giumanini, Angelo G.
Tetrahedron, 2000 , vol. 56, # 22 p. 3625 - 3633
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Uchiyama; Yoshino; Takemoto; Achiwa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 11 p. 3091 - 3093
