2-胺-5-溴-3-硝苯甲酸合成路线 （共 6 条）
反应条件
1: With dihydrogen peroxide; sodium hydroxide in water
T=0 - 20°C;
2: With hydrogenchloride in water
T=0°C;
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 73 ;
WO 2010/115736 A2
反应条件
bromine; acetic acid
参考文献
English et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 295,301, 2265
反应条件
1.1: acetic anhydride / isopropanol acetate / 60 °C / |Inert atmosphere; |Large scale
2.1: ammonium hydroxide / 2.5 h / 0 - 15 °C / |Inert atmosphere; |Large scale
2.2: 20 °C / |Inert atmosphere; |Large scale
3.1: potassium hydroxide; potassium bromide; potassium hypobromide / water / 75 °C
View Scheme
参考文献
Barkalow, Jufang H.; Breting, Jeffrey; Gaede, Bruce J.; Haight, Anthony R.; Henry, Rodger; Kotecki, Brian; Mei, Jianzhang; Pearl, Kurt B.; Tedrow, Jason S.; Viswanath, Shekhar K.
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 693 - 698
反应条件
1.1: ammonium hydroxide / 2.5 h / 0 - 15 °C / |Inert atmosphere; |Large scale
1.2: 20 °C / |Inert atmosphere; |Large scale
2.1: potassium hydroxide; potassium bromide; potassium hypobromide / water / 75 °C
View Scheme
参考文献
Barkalow, Jufang H.; Breting, Jeffrey; Gaede, Bruce J.; Haight, Anthony R.; Henry, Rodger; Kotecki, Brian; Mei, Jianzhang; Pearl, Kurt B.; Tedrow, Jason S.; Viswanath, Shekhar K.
Organic Process Research and Development, 2007 , vol. 11, # 4 p. 693 - 698
参考文献
English et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 295,301, 2265
反应条件
in methanol; diethyl ether
参考文献
MERCK SERONO S.A.; THUNUGUNTLA, Siva Sanjeeva Rao; SUBRAMANYA, Hosahalli; KUNNAM, Satish Reddy; SANIVARU VIJAY, Sekhar Reddy; BINGI, Chakrapani; KUSANUR, Raviraj; SCHWARZ, Matthias; ARLT, Michael
Patent: WO2010/115736 A2, 2010 ;
Location in patent: Page/Page column 73 ;
WO 2010/115736 A2
