1.1: hydrogenchloride; acetic acid / water / 20 - 90 °C
1.2: 2 h / 80 °C
2.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / chlorobenzene / 85 - 110 °C
2.3: 1 h / 0 °C
View Scheme
参考文献
Koeberle, Solveigh C.; Fischer, Stefan; Schollmeyer, Dieter; Schattel, Verena; Gruetter, Christian; Rauh, Daniel; Laufer, Stefan A.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5868 - 5877