N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane

1: Na / ethanol / 48 h 2: KOH / ethanol / 0.5 h / Heating 3: 95 percent / H2 / Pd/C / ethyl acetate / 4 h / 23 °C / 760 Torr 4: oxalyl chloride / Heating 5: diethyl ether / 2 h / Ambient temperature 6: 80 percent / Rh2(OAc)4 / CH2Cl2 / 2 h / Ambient temperature 7: 44 percent / trifluoroacetic acid; CH2Cl2 / 0.17 h / Ambient temperature View Scheme

1: 95 percent / H2 / Pd/C / ethyl acetate / 4 h / 23 °C / 760 Torr 2: oxalyl chloride / Heating 3: diethyl ether / 2 h / Ambient temperature 4: 80 percent / Rh2(OAc)4 / CH2Cl2 / 2 h / Ambient temperature 5: 44 percent / trifluoroacetic acid; CH2Cl2 / 0.17 h / Ambient temperature View Scheme

1: KOH / ethanol / 0.5 h / Heating 2: 95 percent / H2 / Pd/C / ethyl acetate / 4 h / 23 °C / 760 Torr 3: oxalyl chloride / Heating 4: diethyl ether / 2 h / Ambient temperature 5: 80 percent / Rh2(OAc)4 / CH2Cl2 / 2 h / Ambient temperature 6: 44 percent / trifluoroacetic acid; CH2Cl2 / 0.17 h / Ambient temperature View Scheme

toluene-4-sulfonic acid; acetic acid

in dichloromethane; trifluoroacetic acid 0.166667 h; Ambient temperature;

1: 80 percent / Rh2(OAc)4 / CH2Cl2 / 2 h / Ambient temperature 2: 44 percent / trifluoroacetic acid; CH2Cl2 / 0.17 h / Ambient temperature View Scheme

暂无反应条件数据

(i) Li, liq. NH3, THF, (ii) NaOH, MeOH; Multistep reaction;