1-(2-氰基乙基)-1-甲酰基环己烷合成路线 （共 7 条）
反应条件
ammonia; nickel T=120°C; P=514855 Torr; Hydrogenation;
参考文献
Liebowitz; Belair; Witiak; Lednicer
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 5 p. 439 - 444
反应条件
N-benzyl-trimethylammonium hydroxide in 1,4-dioxane
T=0 - 20°C;
参考文献
Liebowitz; Belair; Witiak; Lednicer
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 5 p. 439 - 444
反应条件
1: 95 percent / MgSO4 / CH2Cl2 / Heating
2: hydroquinone / toluene / Heating
3: HCl / CH2Cl2; H2O
View Scheme
参考文献
Reid, Mark; Taylor, Richard J. K.
Tetrahedron Letters, 2004 , vol. 45, # 21 p. 4181 - 4183
反应条件
1: hydroquinone / toluene / Heating
2: HCl / CH2Cl2; H2O
View Scheme
参考文献
Reid, Mark; Taylor, Richard J. K.
Tetrahedron Letters, 2004 , vol. 45, # 21 p. 4181 - 4183
反应条件
toluene-4-sulfonic acid in ethylene glycol; benzene
参考文献
Rohm and Haas Company
Patent: US4400512 A1, 1983 ;
反应条件
toluene-4-sulfonic acid in benzene
3 h; Heating;
参考文献
Liebowitz; Belair; Witiak; Lednicer
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 5 p. 439 - 444
反应条件
1: 91 percent / p-toluene sulfonic acid / benzene / 3 h / Heating
2: LiAlH4 / tetrahydrofuran / 3 h / Heating
3: 10percent aq. HCl / 1 h / Ambient temperature
4: 10percent aq. NaOH / 1 h / Ambient temperature; pH = 9
View Scheme
参考文献
Liebowitz; Belair; Witiak; Lednicer
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 5 p. 439 - 444
