3-(三甲基锡烷基)-吡啶合成路线 （共 36 条）
反应条件
tetrakis(triphenylphosphine) palladium(0) in xylene 12 h; Heating;
参考文献
Yamamoto, Yutaka; Azuma, Yutaka; Mitoh, Hiroyuki
Synthesis, 1986 , # 7 p. 564 - 565
反应条件
copper(l) iodide; C37H51ClFeNPPd; cesium fluoride in N,N-dimethyl-formamide T=80°C; Stille Cross Coupling; 12 h; Inert atmosphere;
参考文献
Ma, Gaizhi; Leng, Yuting; Wu, Yusheng; Wu, Yangjie
Tetrahedron, 2013 , vol. 69, # 2 p. 902 - 909
反应条件
iodine in chloroform 0.25 h; Ambient temperature;
参考文献
Yamamoto, Yutaka; Yanagi, Akihiko
Heterocycles, 1981 , vol. 16, # 7 p. 1161 - 1164
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene T=110°C; 4 h;
参考文献
Yamamoto, Yutaka; Tanaka, Takuo; Yagi, Masayoshi; Inamoto, Masayuki
Heterocycles, 1996 , vol. 42, # 1 p. 189 - 194
反应条件
copper(l) iodide; triphenyl-arsane; tris-(dibenzylideneacetone)dipalladium(0) in N,N-dimethyl-formamide T=80°C; Substitution; 5 h;
参考文献
Wakabayashi, Shigeharu; Sugihara, Yoshikazu; Takakura, Katsuto; Murata, Shigeru; Tomioka, Hideo; Ohnishi, Shiho; Tatsumi, Kazuyuki
Journal of Organic Chemistry, 1999 , vol. 64, # 19 p. 6999 - 7008
反应条件
dinitrogen tetraoxide in tetrachloromethane; dimethyl sulfoxide T=20°C; 16 h;
参考文献
Fargeas, Valerie; Favresse, Fabien; Mathieu, Didier; Beaudet, Isabelle; Charrue, Pierre; Lebret, Bruno; Piteau, Marc; Quintard, Jean-Paul
European Journal of Organic Chemistry, 2003 , # 9 p. 1711 - 1721
反应条件
n-C4H9Li in diethyl ether; hexane
(Ar); a soln. of n-BuLi in hexane added dropwise at -78°C to an ether soln. of 3-bromopyridine; after 3 h, Me3SnCl in ether added over a period of 10 min at -78°C, stirred for 30 min at -78°C, warmed slowly to room temp.; washed (H2O), the org. phase dried over MgSO4, solvent-removed, chromd. (silica gel, EtOAc/hexane); obtained as an oil;
参考文献
Janka, Mesfin; Anderson, Gordon K.; Rath, Nigam P.
Inorganica Chimica Acta, 2004 , vol. 357, # 8 p. 2339 - 2344
反应条件
bis-triphenylphosphine-palladium(II) chloride in 1,4-dioxane
T=20 - 90°C;
参考文献
Hester JR., Jackson B.
Patent: US2004/14967 A1, 2004 ;
Location in patent: Page 60 ;
反应条件
1: 3-bromo-pyridine With n-butyllithium in hexanes; diethyl ether
T=-78°C; 0.166667 h;
2: trimethylstannyl chloride in hexanes; diethyl ether
T=-78 - 20°C; 1.33333 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/133904 A2, 2006 ;
Location in patent: Page/Page column 23 ;
反应条件
sodium in ammonia
Irradiation (UV/VIS); (CH3)3SnCl was dissolved in ammonia, Na metal was added until a blue color persisted for 5 min, when the blue color dissapeared, phosphate esterwas added, the mixt. was UV-irradiated with stirring for 3 h; excess of CH3I was added, NH3 was evapd., the residue was treated with water, extd. with ether, washed with aq. satd. soln. of NaCl, dried over MgSO4, recrystd. in ethanol;
参考文献
Chopa, Alicia B.; Lockhart, Maria T.; Dorn, Viviana B.
Organometallics, 2002 , vol. 21, # 7 p. 1425 - 1429
