反应条件
1.1: sodium hydride / toluene; mineral oil / 0.33 h / 0 - 20 °C 1.2: 16 h / 20 °C 1.3: 20 °C 2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h 3.1: sodium hydride / copper(l) iodide / tetrahydrofuran; mineral oil / 16 h / 20 °C / Inert atmosphere 3.2: 20 °C / Inert atmosphere View Scheme
参考文献
ARROW THERAPEUTICS LIMITED; ASTRAZENECA UK LIMITED; BARNES, Michael, Christopher, Stratton; FLACK, Stephen, Sean; FRASER, Ian; LUMLEY, James, Andrew; PANG, Pui Shan; SPENCER, Keith, Charles; TIBERGHIEN, Nathalie, Anne, Laure; TOMKINSON, Gary, Peter
Patent: WO2011/151651 A1, 2011 ;
WO 2011/151651 A1