反应条件
1: SOCl2 / 1 h / Ambient temperature
2: 32 percent / pyridine / CH2Cl2 / Ambient temperature
3: 1.) 9-BBN, 2.) 1M aq. NaOH, 27percent aq. H2O2 / 1.) THF, RT, 3 h, 2.) THF, 40 deg C, 1 h
4: CBr4, PPh3 / CH2Cl2 / 2 h / Ambient temperature
5: 1.) NaH, 2.) KI / 1.) DMF, RT, 10 min, 2.) DMF, 70 deg C, 4 h
6: 90 percent / borane-THF complex / tetrahydrofuran / 1 h / Heating
View Scheme
参考文献
Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341
